Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	87541
Country	China

Received	2023-08-15 13:38
Peer-Review Started	2023-08-15 13:40
To Make the First Decision
Return for Revision	2023-09-03 02:34
Revised	2023-09-15 11:59
Second Decision	2023-10-13 09:33
Accepted by Journal Editor-in-Chief	2023-10-12 11:06
Accepted by Executive Editor-in-Chief	2023-10-17 08:29
Articles in Press	2023-10-17 08:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-10-05 03:32
Typeset the Manuscript	2023-10-26 03:04
Publish the Manuscript Online	2023-11-27 10:26

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Comprehensive treatment and a rare presentation of Cronkhite–Canada syndrome: Two case reports and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Qing Lv, Mei-Lan Wang, Tong-Yu Tang and Yu-Qin Li
ORCID	Author(s) ORCID Number Yu-Qin Li http://orcid.org/0000-0002-5505-3906
Funding Agency and Grant Number	Funding Agency Grant Number Jilin Provincial Science and Technology Department Project 20200201343JC Science and Technology Development Program of Jilin Province 20210402013GH
Corresponding Author	Yu-Qin Li, MD, Chief Physician, Professor, Department of Gastroenterology, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. liyuq@jlu.edu.cn
Key Words	Cronkhite–Canada syndrome; Clinical features; Gastrointestinal polyps; Hypothyroidism; Case report
Core Tip	Cronkhite–Canada syndrome (CCS) is a rare, non-genetic syndrome characterized by ectodermal abnormalities and diffuse gastrointestinal polyps with protein loss. To date, 7 patients with CCS combined with hypothyroidism have been identified. We report two cases, one of which is combined with hypothyroidism. Through indexing and analyzing PubMed, Web of Science, and Embase databases, we summarized the clinical characteristics of CCS combined with hypothyroidism. Additionally, we concluded that pharmacotherapy can induce and maintain remission in CCS patients, with adjuvant endoscopic mucosal resection, long-term follow-up, and endoscopic surveillance being necessary.
Publish Date	2023-11-27 10:26
Citation	Lv YQ, Wang ML, Tang TY, Li YQ. Comprehensive treatment and a rare presentation of Cronkhite–Canada syndrome: Two case reports and review of literature. World J Gastrointest Surg 2023; 15(11): 2646-2656
URL	https://www.wjgnet.com/1948-9366/full/v15/i11/2646.htm
DOI	https://dx.doi.org/10.4240/wjgs.v15.i11.2646

Full Article (PDF)	WJGS-15-2646-with-cover.pdf
Full Article (Word)	WJGS-15-2646.docx
CARE Checklist–2016	87541-CARE Checklist (2016) .pdf
Manuscript File	87541_Auto_Edited-CL-Filipodia-JLW.docx
Answering Reviewers	87541-Answering reviewers.pdf
Audio Core Tip	87541-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	87541-Conflict-of-Interest Disclosure Form-revision.pdf
Copyright License Agreement	87541-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	87541-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	87541-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	87541-Language certificate.pdf
Peer-review Report	87541-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	87541-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	87541-Bing-Lin C-2.png
Scientific Editor Work List	87541-Scientific editor work list.pdf
CrossCheck Report	87541-CrossCheck.png
CrossCheck Report	87541-CrossCheck report.pdf