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Articles Published Processes
12/14/2023 5:08:46 AM | Browse: 162 | Download: 976
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Received |
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2023-08-19 00:33 |
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Peer-Review Started |
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2023-08-15 13:42 |
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First Decision by Editorial Office Director |
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2023-10-09 13:59 |
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Return for Revision |
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2023-10-09 13:59 |
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Revised |
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2023-10-16 13:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-11-06 09:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-11-09 06:56 |
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Articles in Press |
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2023-11-09 06:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-06 09:39 |
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Publish the Manuscript Online |
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2023-12-14 05:08 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Paired-related homeobox 1 induces epithelial-mesenchymal transition in oesophageal squamous cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Bao Guo, Ming Du, Bin Wang, Li Zhong, Zhong-Xue Fu and Jin-Lai Wei |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Li Zhong, PhD, Academic Editor, Doctor, Doctor, Researcher, Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang Street, Chongqing 400016, China. zhongli401@126.com |
| Key Words |
Paired-related homeobox 1; Oesophageal squamous cancer; Epithelial-mesenchymal transition; Cancer metastasis |
| Core Tip |
This study aims to assess the significance of paired-related homeobox 1 (PRRX1) expression and investigate the mechanism of epithelial-mesenchymal transition (EMT) in oesophageal cancer metastasis. PRRX1 is expressed at high levels in oesophageal cancer specimens and is closely related to tumour metastasis in patients with oesophageal cancer. Regulation of PRRX1 expression might exert obvious effects on cell proliferation, especially the migration and invasion of oesophageal cancer cells. Moreover, silencing PRRX1 expression using a short hairpin RNA produced the opposite effects. In addition, when PRRX1 was overexpressed, inhibition of the Wnt/β-catenin pathway with XAV939 negated the effect of PRRX1 on EMT, whereas when PRRX1 was downregulated, activation of the Wnt/β-catenin pathway with LiCl impaired the effect on EMT. These observations indicate that PRRX1 is upregulated in oesophageal cancer is closely correlated with cancer metastasis. Additionally, PRRX1 induces EMT in oesophageal cancer metastasis through activation of Wnt/β-catenin signalling. |
| Publish Date |
2023-12-14 05:08 |
| Citation |
Guo JB, Du M, Wang B, Zhong L, Fu ZX, Wei JL. Paired-related homeobox 1 induces epithelial-mesenchymal transition in oesophageal squamous cancer. World J Gastrointest Oncol 2023; 15(12): 2185-2196 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i12/2185.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i12.2185 |
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