| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lin-Xin Zheng, Kai-En Guo, Jia-Qi Huang, Miao-Hua Liu, Bai-Ling Deng, Duan-Yong Liu, Bu-Gao Zhou, Wen Zhou, You-Bao Zhong and Hai-Mei Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81760808, 82260863 |
| Scientific and Technological Project of Education Department of Jiangxi Province |
No. GJJ181582 |
| Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program |
No. CXTD22008 |
| Key Laboratory of Pharmacodynamics and Quality Evaluation on anti-Inflammatory Chinese Herbs, Jiangxi Administration of Traditional Chinese Medicine |
No. 202208 |
|
| Corresponding Author |
Wen Zhou, MD, Assistant Professor, Nanchang Medical College, Nanchang Medical College, No. 689 Huiren Road, Nanchang 330052, Jiangxi Province, China. zw1103380809@163.com |
| Key Words |
Curcumin; Ulcerative colitis; Memory T helper; Memory follicular T helper; JAK1/STAT3/SOCS |
| Core Tip |
Memory T cells (mTh) are formed by the differentiation of initial T cells following antigenic stimulation and have a long lifespan. The dysfunction and out-of-balance of mTh and their subsets destroy immune homeostasis to induce autoimmune diseases including inflammatory bowel disease. Finding new drugs for inflammatory bowel disease (IBD) treatment from natural plant medicine and traditional Chinese medicine is a research hotspot. Cur can regulate memory B cells and other immune cells to effectively treat experimental colitis. However, whether Cur can regulate mTh cell- and mfTh cell-mediated homeostasis to treat IBD remains unclear. We here indicated that Cur regulates the mTh/memory follicular T helper cell homeostasis to reduce dextran sulfate sodium-induced colonic pathological injury, which may be achieved by inhibiting the JAK1/STAT3/SOCS signaling pathway. |
| Publish Date |
2023-09-20 10:11 |
| Citation |
Zheng LX, Guo KE, Huang JQ, Liu MH, Deng BL, Liu DY, Zhou BG, Zhou W, Zhong YB, Zhao HM. Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance. World J Gastroenterol 2023; 29(36): 5226-5239 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i36/5226.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i36.5226 |
