Publication Name	World Journal of Gastroenterology
Manuscript ID	8758
Country	China

Received	2014-01-06 10:29
Peer-Review Started	2014-01-06 19:24
To Make the First Decision	2014-03-13 18:59
Return for Revision	2014-03-19 21:15
Revised	2014-04-09 22:52
Second Decision	2014-05-19 15:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-19 15:32
Articles in Press	2014-05-23 10:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-30 17:14
Typeset the Manuscript	2014-08-15 15:25
Publish the Manuscript Online	2014-08-29 11:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	MicroRNA-218 is upregulated in gastric cancer after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and increases chemosensitivity to cisplatin
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang-Liang Zhang, Hui-Juan Shi, Ji-Ping Wang, Hong-Sheng Tang, Yin-Bing Wu, Zhi-Yuan Fang, Shu-Zhong Cui and Lian-Tang Wang
Funding Agency and Grant Number	Funding Agency Grant Number PhD Start-up Funds of Guangzhou Medical College, Guangdong Province, China 2012C66 PhD Start-up Funds of Guangzhou Medical College, Guangdong Province, China 2012C69 Guangdong Province Natural Science Fund S2013010016662 National Natural Science Foundation of China 81201932 National Natural Science Foundation of China 81372493
Corresponding Author	Correspondence to: Lian-Tang Wang, Professor, Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. wanglt@mail.sysu.edu.cn
Key Words	Advanced gastric cancer; Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy; miR-218; Multi-drug resistance; MicroRNA
Core Tip	MicroRNAs (miRNAs) are short single-stranded RNAs associated with gene regulation at the transcriptional and translational levels. miRNA up- or down regulation has been linked to cancer development. We analyzed miRNA expression in advanced gastric cancers before and after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) to gain further understanding of the molecular mechanisms of CRS + HIPEC. Furthermore, we described the regulation and function of miR-218 in gastric cancer emphatically. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of gastric cancer and can reverse the multi-drug resistance of gastric cell lines.
Publish Date	2014-08-29 11:57
Citation	Zhang XL, Shi HJ, Wang JP, Tang HS, Wu YB, Fang ZY, Cui SZ, Wang LT. MicroRNA-218 is upregulated in gastric cancer after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and increases chemosensitivity to cisplatin. World J Gastroenterol 2014; 20(32): 11347-11355
URL	http://www.wjgnet.com/1007-9327/full/v20/i32/11347.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i32.11347

Full Article (PDF)	WJG-20-11347.pdf
Full Article (Word)	WJG-20-11347.doc
Manuscript File	8758-Review.doc
Answering Reviewers	8758-Answering reviewers.pdf
Copyright License Agreement	8758-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8758-Language certificate.pdf
Peer-review Report	8758-Peer review.pdf
Scientific Editor Work List	8758-Scientific editor work list.pdf