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Articles Published Processes
1/11/2024 6:17:31 AM | Browse: 179 | Download: 557
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Received |
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2023-08-19 14:21 |
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Peer-Review Started |
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2023-08-19 14:23 |
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To Make the First Decision |
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Return for Revision |
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2023-10-18 13:00 |
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Revised |
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2023-10-28 17:47 |
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Second Decision |
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2023-11-24 06:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-12-01 06:42 |
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Articles in Press |
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2023-12-01 06:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-11-21 14:49 |
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Typeset the Manuscript |
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2024-01-04 02:28 |
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Publish the Manuscript Online |
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2024-01-11 06:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Analysis of the potential biological value of pyruvate dehydrogenase E1 subunit β in human cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yao Rong, Song-Hua Liu, Ming-Zheng Tang, Zhi-Hang Wu, Guo-Rong Ma, Xiao-Feng Li and Hui Cai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The 2021 Central-Guided Local Science and Technology Development Fund |
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| Lanzhou COVID-19 Prevention and Control Technology Research Project |
No. 2020-XG-1 |
| Gansu Province Outstanding Graduate Student "Innovation Star" Project |
No. 2022CXZX-748, 2022CXZX-746 |
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| Corresponding Author |
Hui Cai, PhD, Doctor, Doctor, General Clinical Center, Gansu Provincial Hospital, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. caialonteam@163.com |
| Key Words |
Cuprotosis; Pyruvate dehydrogenase E1 subunit β; Pan-cancer; Prognosis; Liver cancer |
| Core Tip |
In this study, the multi-faceted correlation between pyruvate dehydrogenase E1 subunit β (PDHB) expression and pan-cancer development was comprehensively studied using bioinformatics analysis. The regulatory effect of PDHB on the malignant phenotype of liver cancer was specifically verified by cell function experiments. Our research suggests that PDHB is closely related to tumor diagnosis, patient prognosis, and tumor immune microenvironment in a variety of tumors. In vitro experimental results showed that overexpressed PDHB could promote the proliferation, migration, and invasion ability of hepatoma cells. PDHB could be a new tumor marker and a potential target for tumor-targeted therapies. |
| Publish Date |
2024-01-11 06:17 |
| Citation |
Rong Y, Liu SH, Tang MZ, Wu ZH, Ma GR, Li XF, Cai H. Analysis of the potential biological value of pyruvate dehydrogenase E1 subunit β in human cancer World J Gastrointest Oncol 2024; 16(1): 144-181 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i1/144.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i1.144 |
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