Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	87622
Country	China

Received	2023-08-19 15:52
Peer-Review Started	2023-08-19 15:54
To Make the First Decision
Return for Revision	2023-12-05 06:10
Revised	2023-12-13 06:59
Second Decision	2024-01-09 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-09 04:16
Articles in Press	2024-01-09 04:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-26 00:45
Publish the Manuscript Online	2024-02-02 09:42

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yao Rong, Ming-Zheng Tang, Song-Hua Liu, Xiao-Feng Li and Hui Cai
ORCID	Author(s) ORCID Number Hui Cai http://orcid.org/0000-0001-5857-1744
Funding Agency and Grant Number	Funding Agency Grant Number 2021 Central-Guided Local Science and Technology Development Fund; National Key Research and Development Program 2018YFC1311506 Gansu Provincial People’s Hospital Intramural Cultivation Key Project 19SYPYA-1 Lanzhou COVID-19 Prevention and Control Technology Research Project 2020-XG-1
Corresponding Author	Hui Cai, PhD, Doctor, Doctor, General Surgery Clinical Medical Center, Gansu Provincial Hospital, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. caialonteam@163.com
Key Words	COVID-19; Liver cancer; Differentially expressed genes; Hub genes; Pathogenesis
Core Tip	In this study, bioinformatics analysis was used as a bridge to correlate coronavirus disease 2019 (COVID-19) with liver cancer to explore the correlation and common molecular mechanisms between the two. This study explored the common differentially expressed genes between COVID-19 and liver cancer, from which key hub genes were identified and analyzed for protein-protein interaction network topology as well as Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment. The expression of some of the hub genes in different liver cancer cells was specifically verified by quantitative reverse transcriptase polymerase chain reaction. Our study suggests that the pathogenic association and regulatory mechanism of COVID-19 with liver cancer may be due to the role of specific hub genes, such as PDZ binding kinase, targeting protein for xklp2, aurora kinase B, etc. and the mediation of P53 signaling pathway.
Publish Date	2024-02-02 09:42
Citation	Rong Y, Tang MZ, Liu SH, Li XF, Cai H. Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer. World J Gastrointest Oncol 2024; 16(2): 436-457
URL	https://www.wjgnet.com/1948-5204/full/v16/i2/436.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i2.436

Full Article (PDF)	WJGO-16-436-with-cover.pdf
Full Article (Word)	WJGO-16-436.docx
Manuscript File	87622_Auto_Edited-YJP.docx
Answering Reviewers	87622-Answering reviewers.pdf
Audio Core Tip	87622-Audio core tip.m4a
Biostatistics Review Certificate	87622-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	87622-Conflict-of-interest statement.pdf
Copyright License Agreement	87622-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	87622-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	87622-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	87622-Language certificate.pdf
Supplementary Material	87622-Supplementary material.pdf
Peer-review Report	87622-Peer-review(s).pdf
Scientific Misconduct Check	87622-Bing-Wang JJ-2.png
Scientific Editor Work List	87622-Scientific editor work list.pdf
CrossCheck Report	87622-CrossCheck report.pdf