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Publication Name World Journal of Clinical Cases
Manuscript ID 87655
Country China
Received
2023-08-21 06:23
Peer-Review Started
2023-08-21 06:25
To Make the First Decision
Return for Revision
2023-11-28 01:00
Revised
2023-11-30 16:46
Second Decision
2023-12-15 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2023-12-15 06:50
Articles in Press
2023-12-15 06:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-12-25 03:26
Publish the Manuscript Online
2024-01-02 09:08
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Marker Ki-67 is a potential biomarker for the diagnosis and prognosis of prostate cancer based on two cohorts
Manuscript Source Unsolicited Manuscript
All Author List Zhen Song, Qi Zhou, Jiang-Lei Zhang, Jun Ouyang and Zhi-Yu Zhang
ORCID
Author(s) ORCID Number
Qi Zhou http://orcid.org/0000-0001-6762-4561
Zhi-Yu Zhang http://orcid.org/0000-0001-5499-8011
Funding Agency and Grant Number
Funding Agency Grant Number
Suzhou Science and Technology Project SYS2019053
Corresponding Author Zhi-Yu Zhang, PhD, Doctor, Doctor, Surgeon, Department of Urology, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Gusu District, Suzhou 215000, Jiangsu Province, China. abner_666@126.com
Key Words Marker Ki-67; Prostate cancer; Biomarker; Diagnosis; Prognosis
Core Tip Marker Ki-67 (MKI67) has been established to correlate with the proliferation and metastasis of various malignant tumor cells, including those implicated in prostate cancer (PCa). Our objective is to validate the connection between MKI67 and the diagnosis as well as prognosis of PCa, by deploying two distinct patient cohorts from bioinformatics and clinical data. Within the bioinformatics data cohort, comprising 496 PCa tissue samples juxtaposed with 152 normal controls, we ascertained that MKI67 possesses a strong diagnostic ability for PCa along with a moderate prognostic prediction potential. Similarly, through our retrospective analysis of clinical data from 271 PCa patients, we confirmed the potent diagnostic capacity of MKI67 for PCa and its capability to predict prognosis to a certain extent.
Publish Date 2024-01-02 09:08
Citation Song Z, Zhou Q, Zhang JL, Ouyang J, Zhang ZY. Marker Ki-67 is a potential biomarker for the diagnosis and prognosis of prostate cancer based on two cohorts. World J Clin Cases 2024; 12(1): 32-41
URL https://www.wjgnet.com/2307-8960/full/v12/i1/32.htm
DOI https://dx.doi.org/10.12998/wjcc.v12.i1.32
Full Article (PDF) WJCC-12-32-with-cover.pdf
Full Article (Word) WJCC-12-32.docx
Manuscript File 87655_Auto_Edited-YJP.docx
Answering Reviewers 87655-Answering reviewers.pdf
Audio Core Tip 87655-Audio core tip.mp3
Biostatistics Review Certificate 87655-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 87655-Conflict-of-interest statement.pdf
Copyright License Agreement 87655-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 87655-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 87655-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 87655-Language certificate.pdf
Peer-review Report 87655-Peer-review(s).pdf
Scientific Misconduct Check 87655-Bing-Wang JJ-2.png
Scientific Editor Work List 87655-Scientific editor work list.pdf
CrossCheck Report 87655-CrossCheck report.pdf