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Articles Published Processes
11/14/2023 6:13:55 AM | Browse: 77 | Download: 150
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Received |
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2023-08-27 13:00 |
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Peer-Review Started |
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2023-08-23 03:22 |
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To Make the First Decision |
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Return for Revision |
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2023-09-14 03:12 |
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Revised |
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2023-09-25 10:09 |
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Second Decision |
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2023-10-20 02:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-10-23 06:52 |
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Articles in Press |
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2023-10-23 06:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-10-19 03:16 |
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Typeset the Manuscript |
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2023-11-07 01:57 |
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Publish the Manuscript Online |
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2023-11-14 06:13 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Exploring the targets and molecular mechanism of glycyrrhetinic acid against diabetic nephropathy based on network pharmacology and molecular docking
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fan-Di Meng, Ling Yuan, Duo-Jie Xu, Meng-Ying Che, Shao-Zhang Hou, Dou-Dou Lu, Wen-Jing Liu and Yi Nan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ningxia Natural Science Foundation |
2022AAC02039 |
| National Natural Science Foundation of China |
81860894, 82260879, 81674096 |
| Ningxia Innovation Team of the Foundation and Clinical Researches of Diabetes and its Complications |
NXKJT2019010 |
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| Corresponding Author |
Yi Nan, MD, PhD, Professor, Traditional Chinese Medicine College, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080011@nxmu.edu.cn |
| Key Words |
Network pharmacology; Molecular docking; Diabetic nephropathy; Glycyrrhetinic acid; Mechanism of action |
| Core Tip |
Diabetes nephropathy (DN) brings a huge burden to human health. Through network pharmacology, we found that glycyrrhetinic acid (GA) has a therapeutic effect on DN, and found 186 therapeutic targets. We speculated and verified that GA plays a role in treating DN by regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway, inhibiting the proliferation of HK-2 cells, blocking the cell cycle in the G2/M phase, and reducing apoptosis of HK-2 cells. This study provides a new development direction for the treatment of DN. |
| Publish Date |
2023-11-14 06:13 |
| Citation |
Meng FD, Yuan L, Xu DJ, Che MY, Hou SZ, Lu DD, Liu WJ, Nan Y. Exploring the targets and molecular mechanism of glycyrrhetinic acid against diabetic nephropathy based on network pharmacology and molecular docking. World J Diabetes 2023; 14(11): 1672-1692 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i11/1672.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i11.1672 |
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