Publication Name	World Journal of Diabetes
Manuscript ID	87873
Country	China

Received	2023-08-31 04:32
Peer-Review Started	2023-08-31 04:33
First Decision by Editorial Office Director	2023-12-25 07:18
Return for Revision	2023-12-25 07:18
Revised	2024-01-06 12:37
Publication Fee Transferred
Second Decision by Editor	2024-01-17 09:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-01-29 06:02
Articles in Press	2024-01-29 06:02
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-06 05:12
Publish the Manuscript Online	2024-03-15 09:49

ISSN	1948-9358 (online)
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Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Shun Wu, Dan-Na Zheng, Cheng Ji, Hui Qian, Juan Jin and Qiang He
ORCID	Author(s) ORCID Number Qi-Shun Wu http://orcid.org/0000-0003-4331-4280 Dan-Na Zheng http://orcid.org/0000-0001-6451-8585 Hui Qian http://orcid.org/0000-0002-0098-3196 Juan Jin http://orcid.org/0000-0003-2513-4665 Qiang He http://orcid.org/0000-0002-7460-649X
Funding Agency and Grant Number	Funding Agency Grant Number Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China LHDMZ22H050001 Construction of Key Projects by Zhejiang Provincial Ministry WKJ-ZJ-2302 Zhejiang Province Chinese Medicine Modernization Program 2020ZX001 Key Project of Scientific Research Foundation of Chinese Medicine 2022ZZ002 “Pioneer” and “LeadingGoose” R&D Program of Zhejiang 2022C03118, 2023C03075 Key Project of Basic Scientific Research Operating Funds of Hangzhou Medical College KYZD202002
Corresponding Author	Qiang He, MD, Chief Physician, Professor, Graduate School, Medical College of Soochow University, No. 1 Shizi Street, Gusu District, Suzhou 215006, Jiangsu Province, China. strong_he@163.com
Key Words	Diabetic kidney disease; MicroRNA-630; Toll-like receptor 4; Mouse model; Renal tubular epithelial cells damage; Hyperglycemic model
Core Tip	This study revealed that microRNA-630 (miR-630) expression in the renal tissue was significantly lower in diabetic kidney disease (DKD) rats than in normal rats. The miR-630 alleviates renal injury and inflammatory reactions in DKD rats by targeting toll-like receptor 4. Our findings provide new insights into the pathogenesis of DKD indicating that miR-630 may be a potential noninvasive biomarker for diagnosing and predicting the prognosis of DKD.
Publish Date	2024-03-15 09:49
Citation	Wu QS, Zheng DN, Ji C, Qian H, Jin J, He Q. MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4. World J Diabetes 2024; 15(3): 488-501
URL	https://www.wjgnet.com/1948-9358/full/v15/i3/488.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i3.488

Full Article (PDF)	WJD-15-488-with-cover.pdf
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