| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing Gu, Huan Xia, Yue-Qiong Song, Jun Duan, Yun Chen, You Zhang, He-Ping Chen and Li Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Key Research and Development Projects of Sichuan Science and Technology Department |
2023YFS0285 |
| Natural Science Foundation Project of Sichuan Science and Technology Department |
2023NSFSC0613 |
|
| Corresponding Author |
Li Zhang, PhD, Doctor, Doctor, Professor, Department of Elderly Digestive, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, 32 West Section 2, Yihuan Road, Chengdu 610072, Sichuan Province, China. 1262867096@qq.com |
| Key Words |
Ulcerative colitis; SLC6A1; NLRP3; Pyroptosis; Inflammasome |
| Core Tip |
Ulcerative colitis (UC) is an inflammatory condition associated with frequent relapse and recurrence. Dysregulation of intestinal epithelial cells (IECs) and mucosal barrier impairment contribute to sustained inflammation in UC. Hence, an in-depth exploration of the triggers and mechanisms of IEC death could result in efficacious therapeutic options for UC patients. Here, we demonstrated the close involvement of SLC6A14 in promoting pyroptosis in the context of UC by upregulating NLRP3 expression. These findings indicate the potential of targeting SLC6A14/NLRP3 axis-mediated pyroptosis as a promising therapeutic strategy for treating UC. Our research provides valuable insights into the mechanisms driving UC pathogenesis and offers a possible direction for developing innovative treatments to alleviate the impact of this chronic inflammatory disorder. |
| Publish Date |
2024-01-18 09:58 |
| Citation |
Gu Q, Xia H, Song YQ, Duan J, Chen Y, Zhang Y, Chen HP, Zhang L. SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis. World J Gastroenterol 2024; 30(3): 252-267 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i3/252.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i3.252 |
