| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin Zeng, Miao-Hua Liu, Yi Xiong, Lin-Xin Zheng, Kai-En Guo, Hai-Mei Zhao, Yu-Ting Yin, Duan-Yong Liu and Bu-Gao Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81603402, 82060798, 81860791 |
| Special Fund Project for Graduate Innovation of Jiangxi University of Chinese Medicine |
JZYC22S77 |
| Special Fund Project for Graduate Innovation of Jiangxi Province |
YC2022-s840, YC2022-B188 |
| Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program |
CXTD22008 |
| Young and Middle-aged Backbone Talent Project of Jiangxi Administration of Traditional Chinese Medicine |
[2020]05 |
| Young Qhuang Scholars support Project of National Administration of Traditional Chinese Medicine |
[2022]256 |
|
| Corresponding Author |
Bu-Gao Zhou, PhD, Professor, Office of Academic Research, Jiangxi University of Chinese Medicine, No. 1688 Meiling Road, Nanchang 330004, Jiangxi Province, China. 57161998@qq.com |
| Key Words |
Pien Tze Huang; Autoimmune hepatitis; Intestinal microbiota; Memory regulatory T cell; Toll-like receptor signaling |
| Core Tip |
Intestinal microbiota disorder plays an important role in the pathogenesis of autoimmune hepatitis (AIH), which one of main characters is the hypofunction of memory regulatory T (mTreg) cells maintained immune tolerance. The interaction between Treg cells and intestinal microbiota may provide a feasible therapeutic strategy of AIH. As a well-known traditional Chinese medicine, Pien Tze Huang (PTH) can effectively treat AIH in clinic. However, its mechanism still kept unclear. In the present study, PTH regulates intestinal microbiota balance and restore mTreg cells to alleviates experimental AIH, which is closely related to toll-like receptor/CXCL16/CXCR6/nuclear factor-κB signaling pathway. |
| Publish Date |
2023-12-01 06:03 |
| Citation |
Zeng X, Liu MH, Xiong Y, Zheng LX, Guo KE, Zhao HM, Yin YT, Liu DY, Zhou BG. Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells. World J Gastroenterol 2023; 29(45): 5988-6016 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i45/5988.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i45.5988 |
