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Articles Published Processes
11/10/2014 7:09:00 PM | Browse: 1133 | Download: 1238
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Received |
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2014-01-08 13:52 |
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Peer-Review Started |
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2014-01-08 21:40 |
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To Make the First Decision |
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2014-03-13 19:00 |
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Return for Revision |
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2014-03-20 09:15 |
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Revised |
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Second Decision |
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2014-07-22 16:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-07-22 17:05 |
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Articles in Press |
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2014-07-22 18:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-08-30 02:55 |
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Typeset the Manuscript |
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2014-10-25 21:48 |
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Publish the Manuscript Online |
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2014-11-10 19:10 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Resveratrol and genistein inhibition of rat isolated gastrointestinal contractions and related mechanisms
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Li-Xue Zhang, Hong-Fang Li, Long-De Wang, Shan Jin, Xing-Cheng Dou, Zhi-Feng Tian and Qin Ma |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Administration of Lanzhou Scientific Technology |
2010-1-88 |
Gansu Natural Science Fund in China |
1010RJZA111 |
National Natural Science Foundation of China |
21272103 |
National Natural Science Foundation of China |
81360540 |
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Corresponding Author |
Hong-Fang Li, Professor, Key Laboratory of Pre-clinical Study for New Drugs of Gansu Province, Department of Physiology, College of Basic Medicine, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, Gansu Province, China. lihf@lzu.edu.cn |
Key Words |
Ca2+ channel; Gastrointestinal; Motility; Phytoestrogen; Smooth muscle |
Core Tip |
Female hormones can cause gastrointestinal motility disorder and may contribute to irritable bowel syndrome. As analogs of estrogen, the phytoestrogens resveratrol and genistein possess variable degrees of agonistic/antagonistic effects, but little is known about their effects on gastrointestinal motility. The present study demonstrates that, similar to estrogen, resveratrol and genistein attenuate gastrointestinal smooth muscle motility through various mechanisms. The results reflect the physiologic and pharmacologic actions of resveratrol and genistein, provide the pharmacologic guidance for the application of these compounds, and are also very valuable for medicine and nutrition. |
Publish Date |
2014-11-10 19:10 |
Citation |
Zhang LX, Li HF, Wang LD, Jin S, Dou XC, Tian ZF, Ma Q. Resveratrol and genistein inhibition of rat isolated gastrointestinal contractions and related mechanisms. World J Gastroenterol 2014; 20(41): 15335-15342 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i41/15335.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i41.15335 |
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