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Articles Published Processes
1/12/2024 10:36:11 AM | Browse: 247 | Download: 576
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Received |
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2023-09-13 16:41 |
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Peer-Review Started |
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2023-09-13 16:44 |
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To Make the First Decision |
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Return for Revision |
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2023-10-24 07:20 |
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Revised |
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2023-11-03 17:27 |
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Second Decision |
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2023-11-28 10:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-12-13 06:29 |
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Articles in Press |
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2023-12-13 06:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-08 02:41 |
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Publish the Manuscript Online |
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2024-01-12 10:36 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: https://creativecommons.org/Licenses/bync/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Retrospective Study |
| Article Title |
Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Wang, Yang Ou, Xiang-Lian Yuan, Xiu-Fang Zhu, Ben Niu, Zhuang Kang, Bing Zhang, Anwar Ahmed, Guo-Qiang Xing and Heng Su |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Heng Su, MD, PhD, Professor, Department of Endocrinology, the First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming 650032, Yunnan Province, China. su_hen@hotmail.com |
| Key Words |
Hyperaminoacidemia; Branched-chain/aromatic amino acids; New-onset type-2 diabetes; Predictor; Obesity; Sex |
| Core Tip |
Elevated branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) predict diabetes in animals with high sensitivity and specificity (both > 97%) and predict type-2 diabetes mellitus (T2DM) 10-20 years before T2DM onset. However, our results indicate that heterogeneously elevated BCAAs/AAAs among new-onset T2DM patients in differing BMI categories and sex may skew BCAA/AAA prediction of T2DM development among the general population: the greater BCAA/AAA elevation in obese individuals, especially males, would support T2DM prediction in these individuals, whereas the lack of or reduced BCAA/AAA elevation in normal weight and reproductive-aged females may compromise BCAA/AAA prediction of T2DM in these individuals. Potential nutritional, metabolic and molecular mechanisms are discussed. |
| Publish Date |
2024-01-12 10:36 |
| Citation |
Wang M, Ou Y, Yuan XL, Zhu XF, Niu B, Kang Z, Zhang B, Ahmed A, Xing GQ, Su H. Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors. World J Diabetes 2024; 15(1): 53-71 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i1/53.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i1.53 |
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