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Articles Published Processes
12/14/2023 9:36:12 AM | Browse: 180 | Download: 678
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Received |
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2023-09-15 03:23 |
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Peer-Review Started |
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2023-09-15 03:25 |
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To Make the First Decision |
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Return for Revision |
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2023-09-20 07:24 |
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Revised |
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2023-09-29 02:54 |
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Second Decision |
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2023-10-19 02:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-10-23 06:55 |
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Articles in Press |
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2023-10-23 06:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-11-09 16:51 |
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Typeset the Manuscript |
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2023-12-07 04:29 |
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Publish the Manuscript Online |
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2023-12-14 09:36 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Atorvastatin ameliorated myocardial fibrosis in db/db mice by inhibiting oxidative stress and modulating macrophage polarization
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian-Min Song, Meng-Nan Zhao, Gui-Zhi Li, Na Li, Ting Wang and Hong Zhou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health Commission of Hebei Province |
20220998 |
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| Corresponding Author |
Hong Zhou, PhD, Chief Physician, Doctor, Doctor, Department of Endocrinology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. zhoubs2013@163.com |
| Key Words |
Atorvastatin; Diabetic cardiomyopathy; Myocardial fibrosis; Macrophage polarization; Inflammation; Oxidative stress |
| Core Tip |
The occurrence and development of diabetic cardiomyopathy are accompanied by a few pathological mechanisms. The present study displayed that atorvastatin had antioxidant properties on diabetic hearts. Cardiac tissues include a plenty of resident macrophages. In high glucose conditions, macrophages can upregulate glucose uptake and utilization and enhance the production of inflammatory cytokines. Dysregulation of macrophages between M1 and M2 phenotypes causes excessive inflammation and cardiac injury. Our study suggests that administration of atorvastatin attenuates myocardial fibrosis in db/db mice, which may be associated with the anti-oxidative stress and anti-inflammatory effects of atorvastatin on diabetic myocardium through modulating macrophage polarization. |
| Publish Date |
2023-12-14 09:36 |
| Citation |
Song XM, Zhao MN, Li GZ, Li N, Wang T, Zhou H. Atorvastatin ameliorated myocardial fibrosis in db/db mice by inhibiting oxidative stress and modulating macrophage polarization. World J Diabetes 2023; 14(12): 1849-1861 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i12/1849.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i12.1849 |
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