| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of fecal microbiota transplant in management of hepatic encephalopathy: Current trends and future directions
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yash R Shah, Hassam Ali, Angad Tiwari, David Guevara-Lazo, Natalia Nombera-Aznaran, Bhanu Siva Mohan Pinnam, Manesh Kumar Gangwani, Harishankar Gopakumar, Amir H Sohail, SriLakshmiDevi Kanumilli, Ernesto Calderon-Martinez, Geetha Krishnamoorthy, Nimish Thakral and Dushyant Singh Dahiya |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dushyant Singh Dahiya, MD, Doctor, Division of Gastroenterology, Hepatology & Motility, The University of Kansas School of Medicine, No. 2000 Olathe Blvd, Kansas City, KS 66160, United States. dush.dahiya@gmail.com |
| Key Words |
Hepatic encephalopathy; Fecal microbiota transplant; Cognitive impairment; Liver cirrhosis; Chronic liver disease |
| Core Tip |
Hepatic encephalopathy (HE) is a reversible neurocognitive dysfunction and a frequent complication in patients with chronic liver disease. HE results from synergistic interaction between various mechanisms like increased ammonia production, systemic inflammation, disruption of the blood-brain barrier, and impairment of neurotransmission, leading to altered gut-brain-liver axis. Lactulose and rifaximin are the current mainstays of management of HE as they are known to decrease ammonia production. Fecal microbiota transplant is being studied as a potential microbiome targeted therapy that can improve the symptoms of HE by decreasing ammonia production, decreasing systemic inflammation, and improving intestinal barrier function. |
| Publish Date |
2024-01-23 09:31 |
| Citation |
Shah YR, Ali H, Tiwari A, Guevara-Lazo D, Nombera-Aznaran N, Pinnam BSM, Gangwani MK, Gopakumar H, Sohail AH, Kanumilli S, Calderon-Martinez E, Krishnamoorthy G, Thakral N, Dahiya DS. Role of fecal microbiota transplant in management of hepatic encephalopathy: Current trends and future directions. World J Hepatol 2024; 16(1): 17-32 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i1/17.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i1.17 |
