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Articles Published Processes
12/19/2023 6:07:28 AM | Browse: 143 | Download: 424
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Received |
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2023-09-22 09:28 |
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Peer-Review Started |
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2023-09-22 09:31 |
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To Make the First Decision |
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Return for Revision |
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2023-09-29 03:07 |
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Revised |
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2023-10-04 15:55 |
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Second Decision |
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2023-10-27 06:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-10-30 07:43 |
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Articles in Press |
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2023-10-30 07:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-14 04:03 |
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Publish the Manuscript Online |
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2023-12-19 06:07 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kavan Panchal, Bhavya Nihalani, Utsavi Oza, Aarti Panchal and Bhumi Shah |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Bhumi Shah, PhD, Associate Professor, Pharmaceutical Chemistry, L. J. Institute of Pharmacy, Sanand Circle, Sarkhej-Gandhinagar Hwy, Sarkhej, Ahmedabad 382210, Gujarat, India. bhumi197@gmail.com |
| Key Words |
Bitter melon; Momordica charantia; Network pharmacology; Molecular docking; Breast cancer; Indian Medicinal Plants, Phytochemistry and Therapeutics |
| Core Tip |
The phytochemicals and molecular processes in bitter melon that are thought to be involved in the therapy of breast cancer (BRCA) were investigated using network Pharmacology. Our research demonstrated that the anti-BRCA benefits of bitter melon are likely caused by negative regulation of transcription, cell differentiation, apoptosis, proteolysis, negative control of neuron apoptosis, and cell migration. Further discovered nine important pathways like phosphatidylinositol 3-kinase/protein kinase B signaling, transcriptional dysregulation, axon guidance, calcium signaling, focal adhesion, janus kinase-signal transducer and activator of transcription signaling, cyclic adenosine monophosphate signaling, mammalian target of rapamycin signaling, and phospholipase D signaling, are likely to be involved in the mechanism of action of bitter melon for the treatment of BRCA. |
| Publish Date |
2023-12-19 06:07 |
| Citation |
Panchal K, Nihalani B, Oza U, Panchal A, Shah B. Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology. World J Exp Med 2023; 13(5): 142-155 |
| URL |
https://www.wjgnet.com/2220-315x/full/v13/i5/142.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v13.i5.142 |
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