Publication Name	World Journal of Gastroenterology
Manuscript ID	88416
Country	Japan

Received	2023-09-24 07:38
Peer-Review Started	2023-09-24 07:40
To Make the First Decision
Return for Revision	2023-10-29 03:34
Revised	2023-11-02 14:03
Second Decision	2023-12-18 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-12-18 05:36
Articles in Press	2023-12-18 05:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-12-12 02:37
Typeset the Manuscript	2023-12-22 05:34
Publish the Manuscript Online	2023-12-27 05:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gene targeted and immune therapies for nodal and gastrointestinal follicular lymphomas
Manuscript Source	Invited Manuscript
All Author List	Takuya Watanabe
ORCID	Author(s) ORCID Number Takuya Watanabe http://orcid.org/0000-0003-3820-0262
Funding Agency and Grant Number
Corresponding Author	Takuya Watanabe, MD, PhD, Director, Director, Doctor, Doctor, Department of Internal Medicine and Gastroenterology, Watanabe Internal Medicine Aoyama Clinic, 1-2-21 Aoyama, Nishi-ku, Niigata 9502002, Japan. nabetaku@dia-net.ne.jp
Key Words	Gastrointestinal follicular lymphoma; Genetic mutation analysis using next-generation sequencing; MicroRNA; Gene targeted therapy; Immune therapy
Core Tip	Recently, the incidence of follicular lymphoma (FL) has increased in Asia, Europe, and the United States, with the number of gastrointestinal FL cases expected to increase. This article reviews the recent literature on the molecular origins of, innovative treatments for, and clinical trial findings on FL, focusing on gastrointestinal FL. Genetic factors [e.g., t(14;18) translocation and BCL2 overexpression] drive FL growth, while microRNAs aid in its diagnosis and prognosis. Although recent trials have reported enhanced treatment outcomes, curative therapies remain elusive, and combinatorial regimens have not been optimized. Hence, gastroenterologists require a more comprehensive understanding of gastrointestinal FL pathogenesis to facilitate improved therapeutic outcomes.
Publish Date	2023-12-27 05:42
Citation	Watanabe T. Gene targeted and immune therapies for nodal and gastrointestinal follicular lymphomas. World J Gastroenterol 2023; 29(48): 6179-6197
URL	https://www.wjgnet.com/1007-9327/full/v29/i48/6179.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i48.6179

Full Article (PDF)	WJG-29-6179-with-cover.pdf
Full Article (Word)	WJG-29-6179.docx
Manuscript File	88416_Auto_Edited-WangTQ-YJP.docx
Answering Reviewers	88416-Answering reviewers.pdf
Audio Core Tip	88416-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	88416-Conflict-of-interest statement.pdf
Copyright License Agreement	88416-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	88416-Language certificate.pdf
Peer-review Report	88416-Peer-review(s).pdf
Scientific Misconduct Check	88416-Bing-Yan JP-2.png
Scientific Editor Work List	88416-Scientific editor work list.pdf
CrossCheck Report	88416-CrossCheck report.pdf