| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Ang Ma, Li-Xin Wang, Hui Zhang, Han-Zhou Li, Li Dong, Qing-Hai Wang, Yuan-Song Wang, Bao-Chao Pan, Shu-Fang Zhang, Huan-Tian Cui and Shu-Quan Lv |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Foundation of Administration of Traditional Chinese Medicine of Hebei Province, China |
2023257 |
|
| Corresponding Author |
Shu-Quan Lv, Doctor, Chief Physician, Department of Endocrinology, Hebei Cangzhou Hospital of Integrative Medicine, No. 31 Huanghe Road, Cangzhou 061000, Hebei Province, China. czlvshuquan@163.com |
| Key Words |
Diabetic nephropathy; Jianpi Gushen Huayu Decoction; Oxidative stress; Inflammation; Untargeted metabolomics; Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway; c-Jun N-terminal kinase/P38-mediated apoptosis |
| Core Tip |
Traditional Chinese medicine (TCM) has been demonstrated to possess beneficial effects on diabetes and its complications. Elucidating upon these mechanisms can contribute to the modernization of TCM. The dysfunction of metabolism is closely related to the progression of diabetes and diabetic complications. Using untargeted metabolomics can be useful in studying the metabolic regulatory mechanisms of TCM. The current study used untargeted metabolomics to evaluate the differential metabolites in a diabetic nephropathy (DN) mouse model after Jianpi Gushen Huayu Decoction (JPGS) treatment. Moreover, we deeply analyzed the results from metabolomics and tested the potential pathways related to the differential metabolites. Our results revealed that JPGS could markedly treat mice with streptozotocin (STZ)-induced DN. The metabolomics results exhibited that the efficacy of JPGS is possibly related to cysteine and methionine metabolism; alanine, aspartate, and glutamate metabolism; tryptophan metabolism; and riboflavin metabolism. |
| Publish Date |
2024-03-15 09:49 |
| Citation |
Ma ZA, Wang LX, Zhang H, Li HZ, Dong L, Wang QH, Wang YS, Pan BC, Zhang SF, Cui HT, Lv SQ. Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways. World J Diabetes 2024; 15(3): 502-518 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i3/502.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i3.502 |
