Publication Name	World Journal of Gastroenterology
Manuscript ID	8847
Country	Spain

Received	2014-01-09 10:35
Peer-Review Started	2014-01-10 22:17
To Make the First Decision	2014-01-24 11:17
Return for Revision	2014-01-26 17:55
Revised
Second Decision	2014-04-23 09:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-23 10:17
Articles in Press	2014-05-23 10:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-30 11:15
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Relationship between methylation and colonic inflammation in inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Triana Lobatón, Daniel Azuara, Francisco Rodríguez-Moranta, Carolina Loayza, Xavier Sanjuan, Javier de Oca, Ana Fernández-Robles, Jordi Guardiola and Gabriel Capellá
Funding Agency and Grant Number	Funding Agency Grant Number Fondo de Investigación Sanitaria FIS 12/01420 Ministerio de Ciencia e Innovación SAF 09-07319 Ministerio de Ciencia e Innovación 12-33636 Fundació Gastroenterologia Dr. Francisco Vilardell F05-01 Ministerio de Educación y Ciencia Spanish Networks RTICC RD06/0020/0021 Ministerio de Educación y Ciencia Spanish Networks RTICC 1050 Ministerio de Educación y Ciencia Spanish Networks RTICC 1051 Institut d’Investigació Biomédica de Bellvitge (IDIBELL) RD12/0036/0031
Corresponding Author	Triana Lobatón, MD, Department of Gastroenterology, University Hospital of Bellvitge, IDIBELL, Hospitalet del Llobregat, Gran Via 144, 08907 Barcelona, Spain. tlobaton@bellvitgehospital.cat
Key Words	Colonic inflammation; Inflammatory bowel disease; Aberrant methylation; Dysplasia; Colitis associated colorectal cancer
Core Tip	In this paper, we analyze the relationship between the methylation status of selected genes (TGFB2, SLIT2) and the inflammation status (according to endoscopic and histological activity) in ulcerative colitis and Crohn’s colitis patients with increased risks for colorectal cancer. We observed that methylation correlated better with histological activity than with endoscopic activity. SLIT2 and TGFB2 were more frequently methylated in the distal colon. In the multivariate analysis after adjusting for disease extension, disease duration and inflammatory status, only inflammatory status was an independent predictor of methylation. We also observed that the maintenance of histological healing with time might be protective for methylation.
Publish Date	2014-08-18 16:49
Citation	Lobatón T, Azuara D, Rodríguez-Moranta F, Loayza C, Sanjuan X, de Oca J, Fernández-Robles A, Guardiola J, Capellá G. Relationship between methylation and colonic inflammation in inflammatory bowel disease. World J Gastroenterol 2014; 20(30): 10591-10598
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10591.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10591

Full Article (PDF)	WJG-20-10591.pdf
Full Article (Word)	WJG-20-10591.doc
Manuscript File	8847-Review.doc
Answering Reviewers	8847-Answering reviewers.pdf
Copyright License Agreement	8847-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8847-Language certificate.pdf
Peer-review Report	8847-Peer reviews.pdf
Scientific Editor Work List	8847-Scientific editor work list.doc