Publication Name	World Journal of Gastroenterology
Manuscript ID	88496
Country	China

Received	2023-09-26 14:42
Peer-Review Started	2023-09-26 14:43
To Make the First Decision
Return for Revision	2023-12-07 00:19
Revised	2023-12-17 15:38
Second Decision	2024-01-12 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-12 06:00
Articles in Press	2024-01-12 06:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-25 09:00
Publish the Manuscript Online	2024-01-31 07:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases: Mechanisms and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Ya-Wei Bi, Long-Song Li, Nan Ru, Bo Zhang and Xiao Lei
ORCID	Author(s) ORCID Number Ya-Wei Bi http://orcid.org/0000-0003-3762-5920 Long-Song Li http://orcid.org/0000-0002-4000-7501 Nan Ru http://orcid.org/0009-0008-6212-6385 Bo Zhang http://orcid.org/0000-0002-4333-0750 Xiao Lei http://orcid.org/0000-0002-0428-1749
Funding Agency and Grant Number	Funding Agency Grant Number Youth Independent Innovation Science Fund Project from Chinese PLA General Hospital 22QNFC075
Corresponding Author	Xiao Lei, PhD, Chief Physician, Doctor, Department of Radiation Oncology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. 18601758966@163.com
Key Words	Nicotinamide adenine dinucleotide phosphate hydrogen oxides; Pancreatitis; Pancreatic cancer; Reactive oxygen species; Mechanism
Core Tip	Nicotinamide adenine dinucleotide phosphate hydrogen oxides (NOX) plays a significant role in the development of pancreatitis and pancreatic cancer (PC) by contributing to pancreatic fibrosis and inflammation. It achieves this by generating reactive oxygen species, which damage acinar cells, activate pancreatic stellate cells, and induce macrophage polarization. Moreover, NOX promotes PC progression by interfering with abnormal cell apoptosis, initiating the epithelial to mesenchymal transition processes, and leading to cell genomic instability. A thorough understanding of NOX’s involvement in pancreatic diseases is crucial for comprehending the underlying mechanisms of pancreatitis and PC. This review provides a summary of NOX’s potential roles and mechanisms in pancreatic disorders, emphasizing areas that require further investigation.
Publish Date	2024-01-31 07:03
Citation	Bi YW, Li LS, Ru N, Zhang B, Lei X. Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases: Mechanisms and future perspectives. World J Gastroenterol 2024; 30(5): 429-439
URL	https://www.wjgnet.com/1007-9327/full/v30/i5/429.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i5.429

Full Article (PDF)	WJG-30-429-with-cover.pdf
Full Article (Word)	WJG-30-429.docx
Manuscript File	88496_Auto_Edited-YJP.docx
Answering Reviewers	88496-Answering reviewers.pdf
Audio Core Tip	88496-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	88496-Conflict-of-interest statement.pdf
Copyright License Agreement	88496-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88496-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	88496-Language certificate.pdf
Peer-review Report	88496-Peer-review(s).pdf
Scientific Misconduct Check	88496-Bing-Wang JJ-2.png
Scientific Editor Work List	88496-Scientific editor work list.pdf