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Articles Published Processes
1/31/2024 7:03:00 AM | Browse: 133 | Download: 600
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Received |
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2023-09-26 14:42 |
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Peer-Review Started |
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2023-09-26 14:43 |
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To Make the First Decision |
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Return for Revision |
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2023-12-07 00:19 |
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Revised |
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2023-12-17 15:38 |
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Second Decision |
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2024-01-12 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-01-12 06:00 |
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Articles in Press |
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2024-01-12 06:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-25 09:00 |
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Publish the Manuscript Online |
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2024-01-31 07:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases: Mechanisms and future perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ya-Wei Bi, Long-Song Li, Nan Ru, Bo Zhang and Xiao Lei |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Youth Independent Innovation Science Fund Project from Chinese PLA General Hospital |
22QNFC075 |
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| Corresponding Author |
Xiao Lei, PhD, Chief Physician, Doctor, Doctor, Department of Radiation Oncology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. 18601758966@163.com |
| Key Words |
Nicotinamide adenine dinucleotide phosphate hydrogen oxides; Pancreatitis; Pancreatic cancer; Reactive oxygen species; Mechanism |
| Core Tip |
Nicotinamide adenine dinucleotide phosphate hydrogen oxides (NOX) plays a significant role in the development of pancreatitis and pancreatic cancer (PC) by contributing to pancreatic fibrosis and inflammation. It achieves this by generating reactive oxygen species, which damage acinar cells, activate pancreatic stellate cells, and induce macrophage polarization. Moreover, NOX promotes PC progression by interfering with abnormal cell apoptosis, initiating the epithelial to mesenchymal transition processes, and leading to cell genomic instability. A thorough understanding of NOX’s involvement in pancreatic diseases is crucial for comprehending the underlying mechanisms of pancreatitis and PC. This review provides a summary of NOX’s potential roles and mechanisms in pancreatic disorders, emphasizing areas that require further investigation. |
| Publish Date |
2024-01-31 07:03 |
| Citation |
Bi YW, Li LS, Ru N, Zhang B, Lei X. Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases: Mechanisms and future perspectives. World J Gastroenterol 2024; 30(5): 429-439 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i5/429.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i5.429 |
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