Publication Name	World Journal of Methodology
Manuscript ID	88518
Country	Japan

Received	2023-09-29 08:21
Peer-Review Started	2023-09-29 08:25
To Make the First Decision
Return for Revision	2023-12-08 05:29
Revised	2023-12-27 08:07
Second Decision	2024-02-03 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-03 05:46
Articles in Press	2024-02-03 05:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-26 10:10
Publish the Manuscript Online	2024-03-07 09:32

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Rikkunshito increases peripheral incretin-hormone levels in humans and rats
Manuscript Source	Unsolicited Manuscript
All Author List	Hiroshi Kono, Shinji Furuya, Hidenori Akaike, Katsutoshi Shoda, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida and Daisuke Ichikawa
ORCID	Author(s) ORCID Number Hiroshi Kono http://orcid.org/0000-0001-6843-0814 Shinji Furuya http://orcid.org/0000-0002-6766-3779 Hidenori Akaike http://orcid.org/0000-0001-9713-7190 Katsutoshi Shoda http://orcid.org/0000-0002-1011-5579 Yoshihiko Kawaguchi http://orcid.org/0000-0001-8788-9524 Hidetake Amemiya http://orcid.org/0000-0002-4320-755X Hiromichi Kawaida http://orcid.org/0000-0003-3507-0167 Daisuke Ichikawa http://orcid.org/0000-0003-0093-2206
Funding Agency and Grant Number
Corresponding Author	Hiroshi Kono, MD, PhD, Adjunct Associate Professor, First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo 409-3898, Yamanashi, Japan. hkouno@yamanashi.ac.jp
Key Words	Incretin hormone; Japanese traditional herbal medicine; Gastric inhibitory polypeptide; Glucagon-like polypeptide-1; Islet cells; Insulin
Core Tip	This study aimed to investigate the effects of rikkunshito (TJ-43) on gastrointestinal hormones, including gastric inhibitory polypeptide and glucagon-like peptide-1, in humans and rats. As a result, TJ-43 increased incretin hormones, and insulin expression, and suppressed increases in blood glucose levels in human and animal models. Thus, TJ-43 may provide benefits after pancreatic surgery.
Publish Date	2024-03-07 09:32
Citation	Kono H, Furuya S, Akaike H, Shoda K, Kawaguchi Y, Amemiya H, Kawaida H, Ichikawa D. Rikkunshito increases peripheral incretin-hormone levels in humans and rats. World J Methodol 2024; 14(1): 88518
URL	https://www.wjgnet.com/2222-0682/full/v14/i1/88518.htm
DOI	https://dx.doi.org/10.5662/wjm.v14.i1.88518

Full Article (PDF)	WJM-14-88518-with-cover.pdf
The ARRIVE Guidelines	88518-The ARRIVE guidelines.pdf
Manuscript File	88518_Auto_Edited-LJH-YJP.docx
Answering Reviewers	88518-Answering reviewers.pdf
Audio Core Tip	88518-Audio core tip.wav
Biostatistics Review Certificate	88518-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88518-Conflict-of-interest statement.pdf
Copyright License Agreement	88518-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	88518-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	88518-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88518-Language certificate.pdf
Peer-review Report	88518-Peer-review(s).pdf
Scientific Misconduct Check	88518-Bing-Liu JH-2.png
Scientific Misconduct Check	88518-CrossCheck.png
Scientific Editor Work List	88518-Scientific editor work list.pdf
CrossCheck Report	88518-CrossCheck report.pdf