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Articles Published Processes
12/26/2023 2:50:13 AM | Browse: 395 | Download: 1375
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Received |
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2023-09-28 07:30 |
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Peer-Review Started |
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2023-09-28 07:32 |
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First Decision by Editorial Office Director |
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2023-10-23 08:44 |
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Return for Revision |
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2023-10-23 08:44 |
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Revised |
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2023-11-11 20:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-11-23 02:26 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-11-24 08:23 |
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Articles in Press |
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2023-11-24 08:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-13 06:20 |
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Publish the Manuscript Online |
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2023-12-26 02:50 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ejlal Abu-El-Rub, Fatimah Almahasneh, Ramada R Khasawneh, Ayman Alzu'bi, Doaa Ghorab, Rawan Almazari, Huthaifa Magableh, Ahmad Sanajleh, Haitham Shlool, Mohammad Mazari, Noor S Bader and Joud Al-Momani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ejlal Abu-El-Rub, PhD, Assistant Professor, Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid-Shafiq Irshidat Street, Irbid 21163, Jordan. ejlal.abuelrub@yu.edu.jo |
| Key Words |
Mesenchymal stem cells; High glucose; Mitochondrial dynamics; Apoptosis; Poor survival; Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway |
| Core Tip |
Mesenchymal stem cells (MSCs) have significant regenerative properties that make them a potential treatment for many chronic diseases. Among these, diabetes mellitus (DM) was found to benefit from MSCs transplantation in which they restored the damaged tissues and prevented hyperglycemia-related complications. However, these therapeutic are short-lived hindering the clinical use of MSCs in the treatment of DM. This study aims to elucidate the mechanisms of hyperglycemia-induced effects on MSCs which will help in improving the therapeutic functions of these cells in this stress environment. |
| Publish Date |
2023-12-26 02:50 |
| Citation |
Abu-El-Rub E, Almahasneh F, Khasawneh RR, Alzu'bi A, Ghorab D, Almazari R, Magableh H, Sanajleh A, Shlool H, Mazari M, Bader NS, Al-Momani J. Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment. World J Stem Cells 2023; 15(12): 1093-1103 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i12/1093.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i12.1093 |
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