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Articles Published Processes
3/12/2024 10:04:17 AM | Browse: 109 | Download: 479
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Received |
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2023-10-08 01:45 |
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Peer-Review Started |
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2023-10-08 01:47 |
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To Make the First Decision |
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Return for Revision |
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2023-12-02 16:08 |
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Revised |
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2023-12-23 08:46 |
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Second Decision |
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2024-01-19 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-01-19 05:33 |
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Articles in Press |
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2024-01-19 05:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-02-29 04:23 |
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Publish the Manuscript Online |
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2024-03-12 10:04 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Qiao Zhang, Qing-Hao Liu, Lu Liu, Peng-Yu Guo, Run-Ze Wang and Zhi-Chang Ba |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Haiyan Found of Harbin Medical University Cancer Hospital |
JJMS2021-03 |
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| Corresponding Author |
Zhi-Chang Ba, MS, Doctor, Doctor, Department of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin 150010, Heilongjiang Province, China. zlyyyxzx@126.com |
| Key Words |
Photodynamic therapy; Pancreatic cancer; Verteporfin; Mitochondria; Chemotherapy; Gemcitabine |
| Core Tip |
Photodynamic therapy (PDT) for pancreatic cancer (PC) is more effective when the photosensitizer is concentrated in the mitochondria. This study showed that 10 μmol/L verteporfin treatment at various times significantly reduced the survival of human PC cells, but lower concentrations had no discernible results. After gemcitabine treatment, verteporfin was located primarily in the mitochondria. Verteporfin was more prevalent in living than dead cells, and in the latter was found mainly in the mitochondria. This study provides a significant theoretical foundation for using PDT in the comprehensive treatment of PC after neoadjuvant chemotherapy. |
| Publish Date |
2024-03-12 10:04 |
| Citation |
Zhang YQ, Liu QH, Liu L, Guo PY, Wang RZ, Ba ZC. Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria. World J Gastrointest Oncol 2024; 16(3): 968-978 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i3/968.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i3.968 |
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