| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jin-Lian Jiang, Yi-Yang Zhou, Wei-Wei Zhong, Lin-Yan Luo, Si-Ying Liu, Xiao-Yu Xie, Mao-Yuan Mu, Zhi-Gang Jiang, Yuan Xue, Jian Zhang and Yi-Huai He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Research Foundations of Guizhou Province |
No. QKHJC-ZK(2022)YB642 |
| Zunyi Science and Technology Plan Project |
No. ZSKH·HZ(2022)344, No. ZSKH·HZ(2022)360 |
| Zunyi Science and Technology Plan Project |
No. ZYK160 |
| Hubei Province Central Leading Local Science and Technology Development Special Project |
No. 2022BCE030 |
| Changzhou Science and Technology Projects |
No. CE20225054 |
| Bijie City Science and Planning Bureau |
No. BKH(2022)8 |
|
| Corresponding Author |
Yi-Huai He, MD, Director, Director, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. 993565989@qq.com |
| Key Words |
Uridine diphosphate glucuronosyltransferase 1A1; Liver injury progression; Endoplasmic reticulum stress; Oxidative stress; Lipid metabolism disorders |
| Core Tip |
The role and mechanism of hepatic uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) in the progression of liver injury are still not fully understood. This study found that inhibiting compensatory upregulation of UGT1A1 promotes the progression of liver injury. The mechanism may be related to low levels of UGT1A1 exacerbating endoplasmic reticulum stress and oxidative stress, and disrupting lipid metabolism, thereby exacerbating hepatocyte apoptosis and necroptosis. |
| Publish Date |
2024-03-06 06:10 |
| Citation |
Jiang JL, Zhou YY, Zhong WW, Luo LY, Liu SY, Xie XY, Mu MY, Jiang ZG, Xue Y, Zhang J, He YH. Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury. World J Gastroenterol 2024; 30(9): 1189-1212 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i9/1189.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i9.1189 |
