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Articles Published Processes
3/22/2024 11:13:53 AM | Browse: 225 | Download: 1005
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Received |
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2023-10-02 15:17 |
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Peer-Review Started |
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2023-10-02 15:19 |
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First Decision by Editorial Office Director |
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2023-12-08 02:17 |
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Return for Revision |
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2023-12-08 02:17 |
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Revised |
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2023-12-20 14:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-02-19 02:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-02-19 06:32 |
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Articles in Press |
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2024-02-19 06:32 |
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Edit the Manuscript by Language Editor |
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2024-02-12 16:56 |
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Typeset the Manuscript |
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2024-03-13 02:59 |
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Publish the Manuscript Online |
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2024-03-22 11:13 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Translational Research |
| Article Title |
Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo-Tao Duan, Xue-Kai Zhao, Yang-Yang Cui, De-Zheng Liu, Lin Wang, Lei Zhou and XingYuan Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lei Zhou, MD, Full Professor, Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou 256600, Shandong Province, China. dr_zhlei@163.com |
| Key Words |
Genomic instability; Long noncoding RNA; Hepatocellular carcinoma; Prognosis; Diagnosis |
| Core Tip |
Identification of genomic instability (GI)-long non-coding RNAs (LncRNAs) was conducted by combining LncRNA expression and somatic mutation profiles. The GI-LncRNAs were then analyzed for functional enrichment. The GI-derived LncRNA signature (GILncSig) was established in the training set by Cox regression analysis, and its predictive ability was verified in the testing set and TCGA set. A total of 88 GI-LncRNAs were found, and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and GI. We established a GILncSig that can predict the prognosis of hepatocellular carcinoma patients, which will help to guide prognostic evaluation and treatment decisions. |
| Publish Date |
2024-03-22 11:13 |
| Citation |
Duan BT, Zhao XK, Cui YY, Liu DZ, Wang L, Zhou L, Zhang XY. Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma. World J Gastrointest Surg 2024; 16(3): 842-859
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| URL |
https://www.wjgnet.com/1948-9366/full/v16/i3/842.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v16.i3.842 |
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