Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	88581
Country	China

Received	2023-10-02 15:17
Peer-Review Started	2023-10-02 15:19
To Make the First Decision
Return for Revision	2023-12-08 02:17
Revised	2023-12-20 14:56
Second Decision	2024-02-19 02:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-19 06:32
Articles in Press	2024-02-19 06:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-02-12 16:56
Typeset the Manuscript	2024-03-13 02:59
Publish the Manuscript Online	2024-03-22 11:13

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Bo-Tao Duan, Xue-Kai Zhao, Yang-Yang Cui, De-Zheng Liu, Lin Wang, Lei Zhou and XingYuan Zhang
ORCID	Author(s) ORCID Number Bo-Tao Duan http://orcid.org/0000-0003-4892-0036 Xue-Kai Zhao http://orcid.org/0000-0002-7079-9095 Lin Wang http://orcid.org/0000-0002-1834-8078 Lei Zhou http://orcid.org/0000-0003-4615-645X XingYuan Zhang http://orcid.org/0000-0002-1817-8048
Funding Agency and Grant Number
Corresponding Author	Lei Zhou, MD, Full Professor, Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou 256600, Shandong Province, China. dr_zhlei@163.com
Key Words	Genomic instability; Long noncoding RNA; Hepatocellular carcinoma; Prognosis; Diagnosis
Core Tip	Identification of genomic instability (GI)-long non-coding RNAs (LncRNAs) was conducted by combining LncRNA expression and somatic mutation profiles. The GI-LncRNAs were then analyzed for functional enrichment. The GI-derived LncRNA signature (GILncSig) was established in the training set by Cox regression analysis, and its predictive ability was verified in the testing set and TCGA set. A total of 88 GI-LncRNAs were found, and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and GI. We established a GILncSig that can predict the prognosis of hepatocellular carcinoma patients, which will help to guide prognostic evaluation and treatment decisions.
Publish Date	2024-03-22 11:13
Citation	Duan BT, Zhao XK, Cui YY, Liu DZ, Wang L, Zhou L, Zhang XY. Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma. World J Gastrointest Surg 2024; 16(3): 842-859
URL	https://www.wjgnet.com/1948-9366/full/v16/i3/842.htm
DOI	https://dx.doi.org/10.4240/wjgs.v16.i3.842

Full Article (PDF)	WJGS-16-842-with-cover.pdf
Manuscript File	88581_Auto_Edited-JRF-Webster J-YJP.docx
Answering Reviewers	88581-Answering reviewers.pdf
Audio Core Tip	88581-Audio core tip.mp3
Biostatistics Review Certificate	88581-Biostatistics statement.pdf
Clinical Trial Registration Statement	88581-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	88581-Conflict-of-interest statement.pdf
Copyright License Agreement	88581-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	88581-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	88581-Institutional review board statement.pdf
Peer-review Report	88581-Peer-review(s).pdf
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Scientific Editor Work List	88581-Scientific editor work list.pdf
CrossCheck Report	88581-CrossCheck report.pdf
CrossCheck Report	88581-CrossCheck.png