Publication Name	World Journal of Gastroenterology
Manuscript ID	8863
Country	China

Received	2014-01-09 11:28
Peer-Review Started	2014-01-09 21:55
To Make the First Decision	2014-02-26 15:47
Return for Revision	2014-03-11 09:59
Revised	2014-03-31 10:10
Second Decision	2014-05-14 09:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-14 09:32
Articles in Press	2014-05-23 10:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-17 16:03
Typeset the Manuscript	2014-10-15 16:10
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Autobiography
Article Title	Targeted migration of mesenchymal stem cells modified with CXCR4 to acute failing liver improves liver regeneration
Manuscript Source	Unsolicited Manuscript
All Author List	Hu-Cheng Ma, Xiao-Lei Shi, Hao-Zhen Ren, Xian-Wen Yuan and Yi-Tao Ding
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81170418 Natural Science Foundation of Jiangsu Province BK20131084 University Graduate Innovation Program of Jiangsu Province CXZZ13_0062
Corresponding Author	Yi-Tao Ding, MD, Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. yitaoding@hotmail.com
Key Words	Acute liver failure; Cell transplantation; Chemokine CXC receptor 4; Mesenchymal stem cells; Cell mobilization
Core Tip	Mesenchymal stem cell (MSC) transplantation is an effective therapy for acute liver failure (ALF), and is expected to be an alternative to liver transplantation. Many current studies have exhibited poor efficiency of MSC transplantation due to low colonization in the failing liver. We modified MSCs with the chemokine CXC receptor 4 (CXCR4) gene to promote the colonization of MSCs in failing liver depending on the stromal cell-derived factor-1?/CXCR4 axis. In vivo imaging showed that CXCR4-MSCs migrated to the liver in higher numbers than Null-MSCs 1 and 5 d after ALF. Greater colonization led to a longer lifetime and better liver function.
Publish Date	2014-10-29 19:34
Citation	Ma HC, Shi XL, Ren HZ, Yuan XW, Ding YT. Targeted migration of mesenchymal stem cells modified with CXCR4 to acute failing liver improves liver regeneration. World J Gastroenterol 2014; 20(40): 14884-14894
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14884.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14884

Full Article (PDF)	WJG-20-14884.pdf
Full Article (Word)	WJG-20-14884.doc
Manuscript File	8863-Review.doc
Answering Reviewers	8863-Answering reviewers.pdf
Copyright License Agreement	8863-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8863-Language certificate.PDF
Peer-review Report	8863-Peer review.pdf
Scientific Editor Work List	8863-Scientific editor work list.pdf