| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai-Lin Jiang, Xiang-Xiang Wang, Xue-Jiao Liu, Li-Kun Guo, Yong-Qi Chen, Qing-Ling Jia, Ke-Ming Yang and Jiang-Hong Ling |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82174309, 81973774 |
| National Administration of Traditional Chinese Medicine: 2019 Project of Building Evidence-Based Practice Capacity for TCM |
2019XZZX-XH013 |
| Shuguang Hospital Siming Foundation Research Special Project |
SGKJ-202304 |
|
| Corresponding Author |
Jiang-Hong Ling, PhD, Professor, Department of Gastroenterology, Shuguang Hospital, No. 185 Pu’an Road, Huangpu District, Shanghai 200021, China. ljh18817424778@163.com |
| Key Words |
Gastric cancer organoids; Human-derived organoids; Gastric cancer; Cell lines; In vitro research models |
| Core Tip |
This study systematically reviewed the success rate of establishing human-derived gastric cancer organoids (GCOs), highlighting the relatively low overall success rate that is influenced by factors such as sex, tissue source, histological type, and pathological tumor-node-metastasis cancer stage. Our meta-analysis revealed that omitting the Rho Kinase inhibitor Y-27632 and using certain digestive enzymes, such as collagenase, enhanced culture success. These findings suggest potential avenues for improving GCO culture techniques that are crucial for advancing GC research and personalized medicine. |
| Publish Date |
2024-04-11 02:23 |
| Citation |
Jiang KL, Wang XX, Liu XJ, Guo LK, Chen YQ, Jia QL, Yang KM, Ling JH. Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis. World J Gastrointest Oncol 2024; 16(4): 1626-1646 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i4/1626.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i4.1626 |
