| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Lie-Qi Tang, Johnathan Fraebel, Shi Jin, Steven P Jr Winesett, Jane Harrell, Wen-Han Chang and Sam Xianjun Cheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health |
1K08HD079674-01, 1R41HD092133-01 |
| National Institute of Allergy and Infectious Diseases |
1A21AI169282 |
| VA Research Career Scientist Award |
1IK6BX004835 |
|
| Corresponding Author |
Sam Xianjun Cheng, MD, MSc, PhD, Associate Professor, Attending Doctor, Department of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Florida Shands Children’s Hospital, 1600 SW Archer Road, HD 600, Gainesville, FL 32608, United States. sam.cheng@ufl.edu |
| Key Words |
Cholera; Enteric nervous system; Secretory diarrhea; Oral rehydration solution; Calcium-sensing receptor; Gene knockout |
| Core Tip |
Treatment of diarrhea remains a global challenge. Enterotoxins induce diarrhea through direct epithelial action and indirectly by activating the enteric nervous system. Using in vitro models in isolated tissues, we have previously shown that calcium-sensing receptor (CaSR) inhibits both actions. In the present study, we use a mouse model of secretory diarrhea in conjunction with a tissue-specific knockout approach and demonstrate that calcium or calcimimetic via CaSR ameliorates cholera toxin-induced secretory diarrhea in vivo. This study suggests that adding calcium to oral rehydration solution or using calcimimetic to activate intestinal CaSR might represent a new approach for treating secretory diarrheal diseases. |
| Publish Date |
2024-01-18 09:58 |
| Citation |
Tang LQ, Fraebel J, Jin S, Winesett SPJ, Harrell J, Chang WH, Cheng SX. Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice. World J Gastroenterol 2024; 30(3): 268-279 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i3/268.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i3.268 |
