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Articles Published Processes
1/26/2024 7:56:29 AM | Browse: 73 | Download: 94
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Received |
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2023-10-05 18:49 |
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Peer-Review Started |
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2023-10-05 18:51 |
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To Make the First Decision |
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Return for Revision |
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2023-12-06 22:24 |
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Revised |
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2023-12-19 22:50 |
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Second Decision |
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2024-01-08 03:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2024-01-08 07:41 |
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Articles in Press |
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2024-01-08 07:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-20 15:21 |
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Publish the Manuscript Online |
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2024-01-26 07:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Portal hypertension in patients with nonalcoholic fatty liver disease: Current knowledge and challenges
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Anita Madir, Ivica Grgurevic, Emmanuel A Tsochatzis and Massimo Pinzani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ivica Grgurevic, DSc, FEBG, FRCP, MD, Professor, Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Gojko Susak Avenue 6, Zagreb 10000, Croatia. ivica.grgurevic@mef.hr |
| Key Words |
Non-alcoholic fatty liver disease; Portal hypertension; Mechanotransduction; Endothelial dysfunction; Hepatic venous pressure gradient |
| Core Tip |
Portal hypertension (PH) occurs in patients with cirrhosis, but in non-alcoholic fatty liver disease (NAFLD) it is sometimes observed in non-cirrhotic stages due to perisinusoidal fibrosis and damage to liver microcirculation. The severity of PH tends to be underestimated by hepatic venous pressure gradient (HVPG) measurement in NAFLD, potentially due to the presence of pre-sinusoidal component, and some patients decompensate at HVPG < 10 mmHg. Liver elastography needs further validation in obese patients as it might overestimate the severity of PH. While candidate drugs for PH are currently in development, lifestyle changes and modulation of metabolic derangements remain the mainstay of treatment. |
| Publish Date |
2024-01-26 07:56 |
| Citation |
Madir A, Grgurevic I, Tsochatzis EA, Pinzani M. Portal hypertension in patients with nonalcoholic fatty liver disease: Current knowledge and challenges. World J Gastroenterol 2024; 30(4): 290-307 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i4/290.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i4.290 |
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