| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing-Nian Zhou, Quan Zhang, Hong Peng, Yu-Jie Qin, Yu-Hong Liu, Lu Wang, Ming-Liang Cheng, Xin-Hua Luo and Hong Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82060123 |
| Doctoral Start-up Fund of Affiliated Hospital of Guizhou Medical University |
No. gysybsky-2021-28 |
| Fund Project of Guizhou Provincial Science and Technology Department |
No. [2020]1Y299 |
| Guizhou Provincial Health Commission |
No. gzwjk2019-1-082 |
|
| Corresponding Author |
Hong Li, MD, PhD, Doctor, Doctor, Department of Infectious Disease, The affiliated Hospital of Guizhou Medical University, Guizhou Medical University, No. 28 Guiyi Road, Guiyang 550004, Guizhou Province, China. 625062102@qq.com |
| Key Words |
Silent information regulator sirtuin 1; Ferroptosis; Pyroptosis; p53/glutathione peroxidase 4/gasdermin D; Acute liver failure |
| Core Tip |
In our study, we investigated the involvement of ferroptosis and pyroptosis in acute liver failure (ALF) using lipopolysaccharide/D-galactosamine-induced ALF model mice. Our results showed that silent information regulator sirtuin 1 activation alleviated ALF through p53/glutathione peroxidase 4/gasdermin D, which mediated the ferroptosis and pyroptosis crosstalk. Our study established a link between ferroptosis and pyroptosis and the upstream regulatory mechanisms. These results may lead to the identification of potential therapeutic targets for ALF. |
| Publish Date |
2024-03-21 11:37 |
| Citation |
Zhou XN, Zhang Q, Peng H, Qin YJ, Liu YH, Wang L, Cheng ML, Luo XH, Li H. Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis. World J Gastroenterol 2024; 30(11): 1588-1608 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i11/1588.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i11.1588 |
