Publication Name	World Journal of Gastroenterology
Manuscript ID	88684
Country	China

Received	2023-10-05 02:24
Peer-Review Started	2023-10-05 02:26
To Make the First Decision
Return for Revision	2023-12-06 22:29
Revised	2023-12-20 09:49
Second Decision	2024-02-18 07:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-18 07:32
Articles in Press	2024-02-18 07:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-02-15 14:23
Typeset the Manuscript	2024-03-15 03:57
Publish the Manuscript Online	2024-03-21 11:37

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis
Manuscript Source	Unsolicited Manuscript
All Author List	Xing-Nian Zhou, Quan Zhang, Hong Peng, Yu-Jie Qin, Yu-Hong Liu, Lu Wang, Ming-Liang Cheng, Xin-Hua Luo and Hong Li
ORCID	Author(s) ORCID Number Xing-Nian Zhou http://orcid.org/0000-0002-7569-9747 Yu-Jie Qin http://orcid.org/0000-0002-8674-7492 Yu-Hong Liu http://orcid.org/0009-0005-6346-7999 Lu Wang http://orcid.org/0009-0008-7403-3434 Ming-Liang Cheng http://orcid.org/0000-0002-2525-3595 Xin-Hua Luo http://orcid.org/0000-0002-1140-2588 Hong Li http://orcid.org/0000-0003-0601-3198
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82060123 Doctoral Start-up Fund of Affiliated Hospital of Guizhou Medical University No. gysybsky-2021-28 Fund Project of Guizhou Provincial Science and Technology Department No. [2020]1Y299 Guizhou Provincial Health Commission No. gzwjk2019-1-082
Corresponding Author	Hong Li, MD, PhD, Doctor, Doctor, Department of Infectious Disease, The affiliated Hospital of Guizhou Medical University, Guizhou Medical University, No. 28 Guiyi Road, Guiyang 550004, Guizhou Province, China. 625062102@qq.com
Key Words	Silent information regulator sirtuin 1; Ferroptosis; Pyroptosis; p53/glutathione peroxidase 4/gasdermin D; Acute liver failure
Core Tip	In our study, we investigated the involvement of ferroptosis and pyroptosis in acute liver failure (ALF) using lipopolysaccharide/D-galactosamine-induced ALF model mice. Our results showed that silent information regulator sirtuin 1 activation alleviated ALF through p53/glutathione peroxidase 4/gasdermin D, which mediated the ferroptosis and pyroptosis crosstalk. Our study established a link between ferroptosis and pyroptosis and the upstream regulatory mechanisms. These results may lead to the identification of potential therapeutic targets for ALF.
Publish Date	2024-03-21 11:37
Citation	Zhou XN, Zhang Q, Peng H, Qin YJ, Liu YH, Wang L, Cheng ML, Luo XH, Li H. Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis. World J Gastroenterol 2024; 30(11): 1588-1608
URL	https://www.wjgnet.com/1007-9327/full/v30/i11/1588.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i11.1588

Full Article (PDF)	WJG-30-1588-with-cover.pdf
The ARRIVE Guidelines	88684-The ARRIVE guidelines.pdf
Manuscript File	88684_Auto_Edited-XLQ-WangTQ-YJP.docx
Answering Reviewers	88684-Answering reviewers.pdf
Audio Core Tip	88684-Audio core tip.m4a
Biostatistics Review Certificate	88684-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88684-Conflict-of-interest statement .pdf
Copyright License Agreement	88684-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88684-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	88684-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	88684-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88684-Language certificate.pdf
Supplementary Material	88684-Supplementary material.pdf
Peer-review Report	88684-Peer-review(s).pdf
Scientific Misconduct Check	88684-Bing-Qu XL-2.jpg
Scientific Editor Work List	88684-Scientific editor work list.pdf
CrossCheck Report	88684-CrossCheck report.pdf