Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	88686
Country	China

Received	2023-10-05 04:12
Peer-Review Started	2023-10-05 04:14
To Make the First Decision
Return for Revision	2023-12-08 04:16
Revised	2023-12-21 08:36
Second Decision	2024-01-18 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-18 05:29
Articles in Press	2024-01-18 05:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-04 01:29
Publish the Manuscript Online	2024-03-12 10:04

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Case Control Study
Article Title	N-glycan biosignatures as a potential diagnostic biomarker for early-stage pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Rong Wen, Xia-Wen Lin, Yu-Wen Zhou, Lei Xu, Jun-Li Zhang, Cui-Ying Chen and Jian He
ORCID	Author(s) ORCID Number Yan-Rong Wen http://orcid.org/0000-0003-1360-456X Cui-Ying Chen http://orcid.org/0000-0002-2136-5725 Jian He http://orcid.org/0000-0001-8140-4610
Funding Agency and Grant Number	Funding Agency Grant Number Affiliated Drum Tower Hospital, Medical School of Nanjing University 2021-LCYJ-MS-11
Corresponding Author	Jian He, Doctor, PhD, Chief Doctor, Department of Nuclear Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. hjxueren@126.com
Key Words	Glycomics; N-glycans; Biomarkers; Pancreatic cancer; Predictive modeling
Core Tip	This study employed a patient cohort to investigate the N-glycan signature of early-stage pancreatic cancer (PC). Serum N-glycans analysis was conducted to identify the serum biomarker signature associated with early-stage pancreatic ductal adenocarcinoma (PDAC), resulting in the identification of nine early-stage PDAC N-glycan signatures. Subsequently, utilizing these biosignatures, a diagnostic model named the “Glyco-model” was developed, demonstrating promising diagnostic performance across all stages of PC. The study revealed that the diagnostic sensitivity for stage I PDAC was determined to be 89.66%. Consequently, this diagnostic model exhibits potential as a prospective strategy for the early detection of PDAC.
Publish Date	2024-03-12 10:04
Citation	Wen YR, Lin XW, Zhou YW, Xu L, Zhang JL, Chen CY, He J. N-glycan biosignatures as a potential diagnostic biomarker for early-stage pancreatic cancer. World J Gastrointest Oncol 2024; 16(3): 659-669
URL	https://www.wjgnet.com/1948-5204/full/v16/i3/659.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i3.659

Full Article (PDF)	WJGO-16-659-with-cover.pdf
Full Article (Word)	WJGO-16-659.docx
STROBE Statement	88686-STROBE statement.pdf
Manuscript File	88686_Auto_Edited-YJP.docx
Answering Reviewers	88686-Answering reviewers.pdf
Audio Core Tip	88686-Audio core tip.m4a
Biostatistics Review Certificate	88686-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88686-Conflict-of-interest statement.pdf
Copyright License Agreement	88686-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88686-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	88686-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	88686-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88686-Language certificate.pdf
Supplementary Material	88686-Supplementary material.pdf
Peer-review Report	88686-Peer-review(s).pdf
Scientific Misconduct Check	88686-Bing-Wang JJ-2.png
Scientific Editor Work List	88686-Scientific editor work list.pdf
CrossCheck Report	88686-CrossCheck report.pdf