| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Case Report |
| Article Title |
Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Three case reports
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Yuan Liu, Hao Chen, Li-Jia He, Chun-Kai Huang, Pu Wang, Zhang-Ru Rui, Jue Wu, Yang Yuan, Yue Zhang, Wen-Ju Wang and Xiao-Dan Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81960136 |
| the Science and Technology Department of Yunnan Province |
202101AT070243 |
|
| Corresponding Author |
Xiao-Dan Wang, MD, Associate Chief Physician, Central Laboratory, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Hospital Affiliated to Kunming Medical University, No. 245 Renmin East Road, Kunming 650051, Yunnan Province, China. wxdky001@163.com |
| Key Words |
Lupus nephritis; Macrophage; Podocyte; Repeat renal biopsy; Thrombotic Microangiopathy; Case report |
| Core Tip |
In this study, we retrospectively analysed the clinical and pathological data of three patients who underwent repeated renal biopsies after treatment for diffuse proliferative lupus nephritis (LN) with different pathological characteristics. Immunohistochemistry and immunofluorescence tests were used to compare the podocyte damage and infiltration of macrophages. Diffuse proliferative LN with different pathological features has different prognoses, and the prognosis of LN with Thrombotic microangiopathy is relatively poor. Podocyte injury and macrophage infiltration may be involved in the pathogenesis of LN. It may be possible to reverse podocyte damage and decrease the infiltrating macrophages of LN patients through effective treatment. |
| Publish Date |
2024-01-02 09:08 |
| Citation |
Liu SY, Chen H, He LJ, Huang CK, Wang P, Rui ZR, Wu J, Yuan Y, Zhang Y, Wang WJ, Wang XD. Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Three case reports. World J Clin Cases 2024; 12(1): 188-195 |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i1/188.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i1.188 |
