Publication Name	World Journal of Diabetes
Manuscript ID	88728
Country	China

Received	2023-10-08 10:36
Peer-Review Started	2023-10-08 10:37
First Decision by Editorial Office Director	2023-12-06 06:12
Return for Revision	2023-12-06 06:12
Revised	2023-12-20 14:28
Publication Fee Transferred
Second Decision by Editor	2024-02-04 05:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-02-27 06:52
Articles in Press	2024-02-27 06:52
Edit the Manuscript by Language Editor	2024-02-03 04:05
Typeset the Manuscript	2024-03-26 07:20
Publish the Manuscript Online	2024-04-12 01:04

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome
Manuscript Source	Unsolicited Manuscript
All Author List	Gu-Lao Zhang, Yuan Liu, Yan-Feng Liu, Xian-Tao Huang, Yu Tao, Zhen-Huan Chen and Heng-Li Lai
ORCID	Author(s) ORCID Number Zhen-Huan Chen http://orcid.org/0000-0001-5819-3392 Heng-Li Lai http://orcid.org/0000-0002-5296-5432
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82000276 the Science and Technology Project of Jiangxi Provincial Health Commission 202310005
Corresponding Author	Heng-Li Lai, MD, Chief Physician, Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Aiguo Road, Donghu District, Nanchang 330000, Jiangxi Province, China. laihengli@163.com
Key Words	Diabetic cardiomyopathy; Teneligliptin; NLRP3; AMPK; Interleukin-1β
Core Tip	Teneligliptin mitigated diabetic cardiomyopathy by mitigating the activation of NLRP3 (NOD-like receptor protein 3) inflammasome. Teneligliptin reversal markedly increased cardiomyocyte area and heart weight/tibia length, reduced fractional shortening, ejection fraction, and heart rate, increased creatine kinase-MB (CK-MB), aspartate transaminase (AST), and lactate dehydrogenase (LDH) levels, and upregulated NADPH oxidase 4 in streptozotocin-induced diabetic mice. Teneligliptin repressed activated NLRP3 inflammasome and increased CK-MB, AST, and LDH levels in glucose-stimulated cardiomyocytes, accompanied by an upregulation of phosphorylated-adenosine 5‘-monophosphate and activated protein kinase.
Publish Date	2024-04-12 01:04
Citation	Zhang GL, Liu Y, Liu YF, Huang XT, Tao Y, Chen ZH, Lai HL. Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome. World J Diabetes 2024; 15(4): 724-734
URL	https://www.wjgnet.com/1948-9358/full/v15/i4/724.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i4.724

Full Article (PDF)	WJD-15-724-with-cover.pdf
The ARRIVE Guidelines	88728-The ARRIVE guidelines.pdf
Manuscript File	88728_Auto_Edited-CL-Filipodia-YJP.docx
Answering Reviewers	88728-Answering reviewers.pdf
Audio Core Tip	88728-Audio core tip.mp3
Biostatistics Review Certificate	88728-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88728-Conflict-of-interest statement.pdf
Copyright License Agreement	88728-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	88728-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	88728-Language certificate.pdf
Peer-review Report	88728-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	88728-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	88728-Bing-Lin C-2.png
Scientific Editor Work List	88728-Scientific editor work list.pdf
CrossCheck Report	88728-CrossCheck.png
CrossCheck Report	88728-CrossCheck report.pdf