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Articles Published Processes
2/4/2024 10:57:42 AM | Browse: 335 | Download: 1277
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Received |
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2023-10-10 08:34 |
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Peer-Review Started |
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2023-10-10 08:35 |
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First Decision by Editorial Office Director |
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2023-11-17 09:20 |
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Return for Revision |
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2023-11-17 09:20 |
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Revised |
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2023-12-12 01:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-01-04 11:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-01-12 07:03 |
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Articles in Press |
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2024-01-12 07:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-29 17:40 |
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Publish the Manuscript Online |
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2024-02-04 10:57 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Huai-Jie Wang, Li-Bin Zhang, Si-Peng Sun, Qing-Tao Yan, Zhi-Qin Gao, Fang-Ming Fu and Mei-Hua Qu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of China |
82070856 |
| the Science and Technology Development Plan of Shandong Medical and Health Science |
202102040075 |
| Scientific Research Plan of Weifang Health Commission |
WFWSJK-2022-010 and WFWSJK-2022-008 |
| Weifang Science and Technology Development Plan |
2021YX071 and 2021YX070 |
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| Corresponding Author |
Mei-Hua Qu, PhD, Professor, Translational Medical Center, Weifang Second People's Hospital, No. 7 Yuanxiao Street, Weifang 261041, Shandong Province, China. qumeihua2016@163.com |
| Key Words |
Duodenal jejunal bypass surgery; Type 2 diabetes mellitus; Neuron apoptosis; Inflammatory; Oxidative stress; Hypothalamic injury |
| Core Tip |
Duodenal jejunal bypass (DJB) increases serum glucagon-like peptide 1 (GLP-1) Levels and enhances brain glucose utilization, playing a positive role in the treatment of diabetes. The GLP-1 signal may play a significant role after DJB surgery in brain injury related to type 2 diabetes mellitus (T2DM). In the current study, DJB surgery increased the serum levels of GLP-1 and upregulated the expression of GLP-1 receptor and antioxidant signaling proteins (Nrf2 and HO-1) in the hypothalamic tissue of T2DM rats. DJB reduced the expression of hypothalamic inflammatory and nerve cell injury-related factors. Therefore, DJB surgery improve oxidative stress and inflammation in the hypothalamus of T2DM rats and reduce neuronal cell injury by activating the GLP-1-mediated Nrf2/HO-1 signaling pathway. |
| Publish Date |
2024-02-04 10:57 |
| Citation |
Wang HJ, Zhang LB, Sun SP, Yan QT, Gao ZQ, Fu FM, Qu MH. Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling. World J Diabetes 2024; 15(2): 287-304 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i2/287.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i2.287 |
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