Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	88762
Country	China

Received	2023-10-13 01:35
Peer-Review Started	2023-10-13 01:37
First Decision by Editorial Office Director	2023-12-08 18:36
Return for Revision	2023-12-10 12:31
Revised	2023-12-19 03:50
Publication Fee Transferred
Second Decision by Editor	2024-01-17 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-01-17 07:34
Articles in Press	2024-01-17 07:34
Edit the Manuscript by Language Editor	2024-01-30 20:35
Typeset the Manuscript	2024-03-25 08:45
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2
Manuscript Source	Unsolicited Manuscript
All Author List	Bin-Sheng Wang, Chen-Li Zhang, Xiang Cui, Qiang Li, Lei Yang, Zhi-Yun He, Ze Yang, Miao-Miao Zeng and Nong Cao
ORCID	Author(s) ORCID Number Bin-Sheng Wang http://orcid.org/0000-0002-1206-5843 Qiang Li http://orcid.org/0000-0003-0923-2927 Ze Yang http://orcid.org/0000-0003-4546-9753 Nong Cao http://orcid.org/0000-0003-2231-0600
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Gansu Province 20JR5RA356 Natural Science Foundation of Gansu Province 22JR5RA511 Lanzhou City Chengguan District Science and Technology Plan Project 2016-7-17
Corresponding Author	Nong Cao, MD, Professor, Department of General Surgery, First Hospital of Lanzhou University, No. 1 Donggang West Road, Lanzhou 730000, Gansu Province, China. caonongldyy@126.com
Key Words	Gastric cancer; Curcumin; Long noncoding RNA AC022424.2; Apoptosis; Akt/PI3K pathway; Lymph metastasis
Core Tip	We investigated the effects of curcumin on gastric cancer cells, and we found that curcumin inhibited the growth and induced gastric cancer cell apoptosis via long noncoding RNA (lncRNA) AC022424.2. Furthermore, the AKT and mTOR signaling pathways are involved in the process. We validated the role of lncRNA AC022424.2 on clinical samples and found that lncRNA AC022424.2 is associated with lymph metastasis.
Publish Date	2024-04-11 02:23
Citation	Wang BS, Zhang CL, Cui X, Li Q, Yang L, He ZY, Yang Z, Zeng MM, Cao N. Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2. World J Gastrointest Oncol 2024; 16(4): 1437-1452
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1437.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1437

Full Article (PDF)	WJGO-16-1437-with-cover.pdf