Publication Name	World Journal of Hepatology
Manuscript ID	88789
Country	France

Received	2023-10-10 11:54
Peer-Review Started	2023-10-10 11:55
To Make the First Decision
Return for Revision	2023-11-27 07:24
Revised	2024-01-26 12:41
Second Decision	2024-03-25 01:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-25 06:12
Articles in Press	2024-03-25 06:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-04-05 22:16
Typeset the Manuscript	2024-05-11 02:51
Publish the Manuscript Online	2024-05-22 11:33

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pathology
Manuscript Type	Retrospective Cohort Study
Article Title	Characteristics of patients with Wilson disease in the United States: An insurance claims database study
Manuscript Source	Unsolicited Manuscript
All Author List	Thomas Daniel-Robin, Pradeep Kumar, Bernard Benichou and Jean-Philippe Combal
ORCID	Author(s) ORCID Number Jean-Philippe Combal http://orcid.org/0000-0003-0740-0026
Funding Agency and Grant Number
Corresponding Author	Jean-Philippe Combal, PharmD, PhD, CEO, Vivet Therapeutics, /, No. 80 Bd Haussmann, 75008, Paris, France. jpcombal@vivet-therapeutics.com
Key Words	Wilson disease; Mortality; Treatment; Copper chelators; Zinc acetate; United States
Core Tip	This insurance claims database study in the United States evaluated data on 5376 patients with a reimbursement claim for Wilson disease (WD), although only patients with a documented treatment of WD can be unequivocally assumed to have the disease. For patients receiving a specific WD treatment, the mean age at death was 57 years, and the standard mortality ratio with respect to the general United States population was 2.19. These findings indicate an important unmet medical need for more effective treatments.
Publish Date	2024-05-22 11:33
Citation	<p>Daniel-Robin T, Kumar P, Benichou B, Combal JP. Characteristics of patients with Wilson disease in the United States: An insurance claims database study. <i>World J Hepatol</i> 2024; 16(5): 791-799</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i5/791.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i5.791

Full Article (PDF)	WJH-16-791-with-cover.pdf
STROBE Statement	88789-STROBE statement.pdf
Manuscript File	88789-Review-FilipodiaCL.docx
Answering Reviewers	88789-Answering reviewers.pdf
Audio Core Tip	88789-Audio core tip.mp4
Biostatistics Review Certificate	88789-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88789-Conflict-of-interest statement.pdf
Copyright License Agreement	88789-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	88789-Signed Informed Consent Form(s) or Document(s)-revision.pdf
Institutional Review Board Approval Form or Document	88789-Institutional review board statement.pdf
Supplementary Material	88789-Supplementary material.pdf
Peer-review Report	88789-Peer-review(s).pdf
Scientific Misconduct Check	88789-Bing-Zhang L-2.png
Scientific Editor Work List	88789-Scientific editor work list.pdf
CrossCheck Report	88789-CrossCheck report.pdf
CrossCheck Report	88789-CrossCheck.png