Publication Name	World Journal of Gastroenterology
Manuscript ID	88790
Country	Australia

Received	2023-10-10 07:44
Peer-Review Started	2023-10-10 07:46
To Make the First Decision
Return for Revision	2023-11-16 05:20
Revised	2023-11-23 00:16
Second Decision	2023-12-08 11:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-12-21 06:17
Articles in Press	2023-12-21 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-12-08 02:36
Typeset the Manuscript	2024-01-03 22:26
Publish the Manuscript Online	2024-01-06 12:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Treat to target in Crohn’s disease: A practical guide for clinicians
Manuscript Source	Invited Manuscript
All Author List	Ashish R Srinivasan
ORCID	Author(s) ORCID Number Ashish R Srinivasan http://orcid.org/0000-0001-5952-1570
Funding Agency and Grant Number
Corresponding Author	Ashish R Srinivasan, FRACP, MBBS, PhD, Consultant Physician-Scientist, Senior Lecturer, Department of Gastroenterology, Austin Health, No. 145 Studley Road, Heidelberg, Melbourne 3083, Victoria, Australia. ashish.srinivasan1@gmail.com
Key Words	Treat to target; Inflammatory bowel disease; Crohn’s disease; Treatment targets; Endoscopic remission; Transmural healing; Time to response; Intestinal ultrasound
Core Tip	A treat-to-target (T2T) approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease. This is achieved through scheduled assessments of disease activity, wherein progress is measured against pre-defined treatment targets, to inform whether current therapy should be continued or modified. Despite its obvious promise, a lack of guidance to support the integration of a T2T approach into clinical practice has the potential to limit widespread uptake. This review seeks to examine the current and emerging literature, to provide clinicians with practical guidance on how to incorporate the principles of T2T into routine clinical practice, as they apply to the management of Crohn’s disease.
Publish Date	2024-01-06 12:15
Citation	Srinivasan AR. Treat to target in Crohn’s disease: A practical guide for clinicians. World J Gastroenterol 2024; 30(1): 50-69
URL	https://www.wjgnet.com/1007-9327/full/v30/i1/50.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i1.50

Full Article (PDF)	WJG-30-50-with-cover.pdf
Full Article (Word)	WJG-30-50.docx
Manuscript File	88790_Auto_Edited-XLQ-WangTQ-YJP.docx
Answering Reviewers	88790-Answering reviewers.pdf
Audio Core Tip	88790-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	88790-Conflict-of-interest statement.pdf
Copyright License Agreement	88790-Copyright license agreement.pdf
Peer-review Report	88790-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	88790-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	88790-Bing-Qu XL-2.jpg
Scientific Editor Work List	88790-Scientific editor work list.pdf
CrossCheck Report	88790-CrossCheck report.pdf