Publication Name	World Journal of Psychiatry
Manuscript ID	88822
Country	China

Received	2023-10-11 03:59
Peer-Review Started	2023-10-11 04:00
To Make the First Decision
Return for Revision	2023-12-26 04:53
Revised	2024-01-09 16:07
Second Decision	2024-02-28 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-28 07:25
Articles in Press	2024-02-28 07:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-10 01:55
Publish the Manuscript Online	2024-04-17 03:42

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Basic Study
Article Title	Tanshinone IIA improves Alzheimer’s disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis
Manuscript Source	Unsolicited Manuscript
All Author List	Long-Xiu Yang, Man Luo and Sheng-Yu Li
ORCID	Author(s) ORCID Number Sheng-Yu Li http://orcid.org/0009-0005-7369-7528
Funding Agency and Grant Number	Funding Agency Grant Number 2020 Guangxi Zhuang Autonomous Region Health Care Commission Self-Financing Research Projects Z20200096 2023 Guangxi University Young and Middle-Aged Teachers’ Basic Research Ability Improvement Project 2023KY0091 National Natural Science Foundation of China 82260241 Natural Science Foundation of Guangxi Province 2015GXNSFAA139171, 2020GXNSFAA259053
Corresponding Author	Sheng-Yu Li, MD, Doctor, Doctor, Teacher, Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning 530000, Guangxi Zhuang Autonomous Region, China. 15177821212@163.com
Key Words	Tanshinone IIA; Alzheimer’s disease; Nuclear-enriched abundant transcript 1; Member of RAS oncogene family Rab22a; Reactive oxygen species
Core Tip	Tanshinone IIA (Tan-IIA), a compound isolated from Salvia miltiorrhiza, demonstrates neuroprotective effects against Alzheimer’s disease (AD). This study reveals that Tan-IIA improves neuronal health, reduces oxidative stress and neuroinflammation, and promotes neural stem cell viability. Importantly, it targets the nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a/nuclear factor kappa-B pathway, offering a potential therapeutic avenue for AD.
Publish Date	2024-04-17 03:42
Citation	Yang LX, Luo M, Li SY. Tanshinone IIA improves Alzheimer’s disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis. World J Psychiatry 2024; 14(4): 563-581
URL	https://www.wjgnet.com/2220-3206/full/v14/i4/563.htm
DOI	https://dx.doi.org/10.5498/wjp.v14.i4.563

Full Article (PDF)	WJP-14-563-with-cover.pdf
The ARRIVE Guidelines	88822-The ARRIVE guidelines.pdf
Manuscript File	88822_Auto_Edited-YJP.docx
Answering Reviewers	88822-Answering reviewers.pdf
Audio Core Tip	88822-Audio core tip.mp3
Biostatistics Review Certificate	88822-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88822-Conflict-of-interest statement.pdf
Copyright License Agreement	88822-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88822-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	88822-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	88822-Language certificate.pdf
Peer-review Report	88822-Peer-review(s).pdf
Scientific Misconduct Check	88822-Bing-Wang JJ-2.png
Scientific Editor Work List	88822-Scientific editor work list.pdf
CrossCheck Report	88822-CrossCheck report.pdf