Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	88828
Country	China

Received	2023-10-11 03:38
Peer-Review Started	2023-10-12 00:29
To Make the First Decision
Return for Revision	2023-10-28 14:02
Revised	2023-12-12 09:16
Second Decision	2024-01-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-05 06:27
Articles in Press	2024-01-05 06:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-27 04:58
Publish the Manuscript Online	2024-02-02 09:42

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Zheng, Jia Lu and Da-Lu Kong
ORCID	Author(s) ORCID Number Da-Lu Kong http://orcid.org/0000-0002-1906-0981
Funding Agency and Grant Number	Funding Agency Grant Number the Science and Technology Development Fund of Tianjin Education Commission for Higher Education 2020KJ133
Corresponding Author	Da-Lu Kong, PhD, Doctor, Doctor, Department of Colorectal Cancer Surgery, National Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, No. 1 Huanhuxi Road Hexi District, Tianjin 300060, China. kongdalu_1@163.com
Key Words	Autophagy; Tumorigenesis; Tumor tissue; Paracarcinoma tissue; Expression; Left/right colon cancer
Core Tip	Autophagy has a dual role in tumorigenesis: inhibiting tumorigenesis under normal conditions and promoting tumor growth once formed. In colon cancer patients with liver metastasis, high cyclin-dependent kinase 9 (CDK9) expression correlated with elevated autophagy levels. Autophagy incidence and expression of BECN1 and ABCG2 differed between left and right colon cancer, potentially contributing to chemotherapy resistance. High CDK9 expression was associated with poor prognosis in colorectal cancer. This study provided a foundation for investigating CDK9 and autophagy inhibitors in combination therapy to enhance tumor cell sensitivity to chemotherapy.
Publish Date	2024-02-02 09:42
Citation	Zheng L, Lu J, Kong DL. Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer. World J Gastrointest Oncol 2024; 16(2): 314-330
URL	https://www.wjgnet.com/1948-5204/full/v16/i2/314.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i2.314

Full Article (PDF)	WJGO-16-314-with-cover.pdf
Full Article (Word)	WJGO-16-314.docx
Manuscript File	88828_Auto_Edited-JLW.docx
Answering Reviewers	88828-Answering reviewers.pdf
Audio Core Tip	88828-Audio core tip.m4a
Biostatistics Review Certificate	88828-Biostatistics statement.pdf
Clinical Trial Registration Statement	88828-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	88828-Conflict-of-interest statement.pdf
Copyright License Agreement	88828-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88828-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	88828-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	88828-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88828-Language certificate.pdf
Supplementary Material	88828-Supplementary material.pdf
Peer-review Report	88828-Peer-review(s).pdf
Scientific Misconduct Check	88828-Bing-Li L-2.png
Scientific Editor Work List	88828-Scientific editor work list.pdf
CrossCheck Report	88828-CrossCheck report.pdf
CrossCheck Report	88828-CrossCheck.png