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3/12/2024 10:04:17 AM | Browse: 335 | Download: 1611
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Received |
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2023-10-11 16:16 |
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Peer-Review Started |
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2023-10-11 16:17 |
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First Decision by Editorial Office Director |
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2023-12-08 19:42 |
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Return for Revision |
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2023-12-09 02:40 |
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Revised |
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2023-12-16 16:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-01-24 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-01-24 06:48 |
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Articles in Press |
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2024-01-24 06:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-02-18 07:40 |
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Publish the Manuscript Online |
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2024-03-12 10:04 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Mei Wang, Zheng-Wei Luo, Yu-Lin Shu, Xiu Zhou, Lin-Qing Wang, Chun-Hong Liang, Chao-Qun Wu and Chang-Ping Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chang-Ping Li, MM, Academic Editor, Additional Professor, Doctor, Doctor, Professor, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. 506854209@qq.com |
| Key Words |
Helicobacter pylori; Gastric cancer; Wnt/β-catenin signaling pathway; Moluodan |
| Core Tip |
Helicobacter pylori (H. pylori) is a pathological bacteria. We explored the effects of H. pylori and the traditional Chinese medicine Moluodan on the Wnt/β-Catenin signaling pathway and precancerous lesions of GC (PLGC). Our experiments successfully established a mouse model of H. pylori infection and PLGC, which serves as a reference for others. Through the gene expression assay, we concluded that H. pylori accelerates the progression of PLGC by promoting the expression of Wnt/β-Catenin signaling pathway, epidermal growth factor (EGF) and c-Myc. Meanwhile, Moluodan can repair the gastric mucosa and delay the progression of PLGC by inhibiting the Wnt/β-Catenin signaling pathway and the expression of EGF and c-Myc. |
| Publish Date |
2024-03-12 10:04 |
| Citation |
Wang YM, Luo ZW, Shu YL, Zhou X, Wang LQ, Liang CH, Wu CQ, Li CP. Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions. World J Gastrointest Oncol 2024; 16(3): 979-990 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i3/979.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i3.979 |
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