Publication Name	World Journal of Gastroenterology
Manuscript ID	88932
Country	China

Received	2023-10-21 06:06
Peer-Review Started	2023-10-21 06:07
To Make the First Decision
Return for Revision	2023-12-05 07:20
Revised	2023-12-18 10:13
Second Decision	2024-01-15 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-15 05:09
Articles in Press	2024-01-15 05:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-05 06:58
Publish the Manuscript Online	2024-02-21 09:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes
Manuscript Source	Unsolicited Manuscript
All Author List	Qing Cui, Hang-Cheng Liu, Wu-Ming Liu, Feng Ma, Yi Lv, Jian-Cang Ma, Rong-Qian Wu and Yi-Fan Ren
ORCID	Author(s) ORCID Number Wu-Ming Liu http://orcid.org/0000-0001-5550-0916 Rong-Qian Wu http://orcid.org/0000-0003-0993-4531 Yi-Fan Ren http://orcid.org/0000-0003-0907-2900
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82100685 Scientific Research Fund of Xi’an Health Commission 2021yb08 Scientific Research Fund of Xi’an Central Hospital 2022QN07 Innovation Capability Support Plan of Xi’an Science and Technology Bureau 23YXYJ0097
Corresponding Author	Yi-Fan Ren, MD, PhD, Assistant Professor, Surgeon, Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 West Fifth Road, Xi’an 710004, Shaanxi Province, China. 871396704@qq.com
Key Words	Autophagy flux; Ferroptosis; Liver injury; Milk fat globule epidermal growth factor 8; αvβ3/5 integrins; Acute pancreatitis
Core Tip	Serum milk fat globule epidermal growth factor 8 (MFG-E8) concentration is negatively correlated with inflammatory severity in acute pancreatitis (AP) patients. Deficiency of MFG-E8 would aggravate the hepatic inflammatory response, and exacerbates the imbalance of liver autophagy flux caused by AP. Eventually leading to ferroptosis. Recombinant MFG-E8 administration restored autophagy flux, reduced ferroptosis and alleviated liver injury in AP in a dose-dependent manner. MFG-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes possibly by binding to integrin αVβ3/5.
Publish Date	2024-02-21 09:11
Citation	Cui Q, Liu HC, Liu WM, Ma F, Lv Y, Ma JC, Wu RQ, Ren YF. Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes. World J Gastroenterol 2024; 30(7): 728-741
URL	https://www.wjgnet.com/1007-9327/full/v30/i7/728.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i7.728

Full Article (PDF)	WJG-30-728-with-cover.pdf
The ARRIVE Guidelines	88932-The ARRIVE guidelines.pdf
Manuscript File	88932_Auto_Edited-YJP.docx
Answering Reviewers	88932-Answering reviewers.pdf
Audio Core Tip	88932-Audio core tip.mp3
Biostatistics Review Certificate	88932-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88932-Conflict-of-interest statement.pdf
Copyright License Agreement	88932-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88932-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	88932-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	88932-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88932-Language certificate.pdf
Supplementary Material	88932-Supplementary material.pdf
Peer-review Report	88932-Peer-review(s).pdf
Scientific Misconduct Check	88932-Bing-Wang JJ-2.png
Scientific Editor Work List	88932-Scientific editor work list.pdf
CrossCheck Report	88932-CrossCheck report.pdf