Publication Name	World Journal of Clinical Cases
Manuscript ID	88939
Country	China

Received	2023-10-16 03:22
Peer-Review Started	2023-10-16 03:22
First Decision by Editorial Office Director	2024-01-24 06:28
Return for Revision	2024-01-24 06:28
Revised	2024-02-05 14:19
Publication Fee Transferred
Second Decision by Editor	2024-03-18 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-18 09:28
Articles in Press	2024-03-18 09:28
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-21 12:54
Publish the Manuscript Online	2024-04-02 09:09

ISSN	2307-8960 (online)
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Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	Successful treatment of Purpureocillium lilacinum pulmonary infection with isavuconazole: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Lin Yang, Jun-Yu Zhang and Jian-Min Ren
ORCID	Author(s) ORCID Number Xue-Lin Yang http://orcid.org/0009-0002-0384-3997 Jun-Yu Zhang http://orcid.org/0000-0002-1013-8172 Jian-Min Ren http://orcid.org/0000-0001-6005-0374
Funding Agency and Grant Number
Corresponding Author	Jun-Yu Zhang, MD, MM, Associate Chief Physician, Chief Doctor, Department of Hematology, Lishui Central Hospital, KuoCang load No. 289, Lishui 323000, Zhejiang Province, China. zhangjunyu815@163.com
Key Words	Purpureocillium lilacinum; Pulmonary infection; Isavuconazole; Case report
Core Tip	Pulmonary infection caused by Purpureocillium lilacinum (P. lilacinum) is exceedingly rare, with uncharacteristic clinical symptoms, signs, and imaging findings. In this case, we reported an older woman with chronic lymphocytic leukemia, long-standing ibrutinib, poor immune function, and fever and cough was admitted to a hematologic department. The patient was diagnosed with P. lilacinum pulmonary infection based on bronchoalveolar lavage fluid culture and metagenomic next-generation sequencing. Conventional antifungal agents often have inherent resistance. Isavuconazole was found to have good safety and efficacy. This is the first known use of isavuconazole for pulmonary P. lilacinum infection. After treatment with isavuconazole, the clinical symptoms of cough and fever improved, and the patient was discharged from the hospital.
Publish Date	2024-04-02 09:09
Citation	Yang XL, Zhang JY, Ren JM. Successful treatment of Purpureocillium lilacinum pulmonary infection with isavuconazole: A case report. World J Clin Cases 2024; 12(10): 1772-1777
URL	https://www.wjgnet.com/2307-8960/full/v12/i10/1772.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i10.1772

Full Article (PDF)	WJCC-12-1772-with-cover.pdf