Publication Name	World Journal of Clinical Oncology
Manuscript ID	8896
Country	United Kingdom

Received	2014-01-11 13:46
Peer-Review Started	2014-01-11 15:42
To Make the First Decision	2014-01-23 17:18
Return for Revision	2014-02-09 21:20
Revised	2014-02-28 18:01
Second Decision	2014-06-11 12:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-11 12:35
Articles in Press	2014-06-11 13:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-24 14:15
Publish the Manuscript Online	2014-08-01 16:16

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Apoptosis block as a barrier to effective therapy in non small cell lung cancer
Manuscript Source	Invited Manuscript
All Author List	Ian Paul and J Mark Jones
Funding Agency and Grant Number
Corresponding Author	J Mark Jones, MD, FRCSEd(CTh), Department of Cardiothoracic Surgery, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, United Kingdom. mark.jones@belfasttrust.hscni.net
Key Words	Apoptosis; Lung cancer; Adjuvant therapy; Mitochondria; BAX; BAK; BCL2
Core Tip	A therapeutic plateau has been reached with the treatment of non-small cell lung cancers with platinum-based combination chemotherapy. New biomarkers of prognosis as well as new therapies focusing on molecular targets are emerging helping to identify patients who are likely to benefit from therapy. These are as yet only available to the minority of patients. Drug resistance remains the major cause for treatment failure. Apoptosis block as a mechanism for drug resistance and potential routes to overcome this will be reviewed.
Publish Date	2014-08-01 16:16
Citation	Paul I, Jones JM. Apoptosis block as a barrier to effective therapy in non small cell lung cancer. World J Clin Oncol 2014; 5(4): 588-594
URL	http://www.wjgnet.com/2218-4333/full/v5/i4/588.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i4.588

Full Article (PDF)	WJCO-5-588.pdf
Full Article (Word)	WJCO-5-588.doc
Manuscript File	8896-Review.docx
Answering Reviewers	8896-Answering reviewers.pdf
Copyright License Agreement	8896-Copyright assignment.pdf
Peer-review Report	8896-Peer review(s).pdf
Scientific Misconduct Check	8896-CrossCheck.jpg
Scientific Editor Work List	8896-Scientific editor work list.pdf