Publication Name	World Journal of Clinical Cases
Manuscript ID	89070
Country	China

Received	2023-10-19 14:37
Peer-Review Started	2023-10-19 14:38
To Make the First Decision
Return for Revision	2024-01-25 21:37
Revised	2024-02-02 15:07
Second Decision	2024-03-04 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-04 08:00
Articles in Press	2024-03-04 08:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-19 03:59
Publish the Manuscript Online	2024-03-25 08:14

ISSN	2307-8960 (online)
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Category	Immunology
Manuscript Type	Clinical and Translational Research
Article Title	Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Yi Yuan, Hui Wu, Qian-Yun Chen, Heng Fan and Bo Shuai
ORCID	Author(s) ORCID Number Heng Fan http://orcid.org/0000-0002-1100-0757 Bo Shuai http://orcid.org/0000-0002-9298-8129
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81774093 National Natural Science Foundation of China 81904009 National Natural Science Foundation of China 81974546 National Natural Science Foundation of China 82174182 Key R&D Project of Hubei Province 2020BCB001
Corresponding Author	Heng Fan, MD, PhD, Chief Physician, Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jie Fang Avenue, Wuhan 430022, Hubei Province, China. fanheng009@aliyun.com
Key Words	Circular RNAs; RNA regulatory network; Ulcerative colitis; New predictive model; Bioinformatics; Diagnose
Core Tip	In this study, we constructed a circRNA-miRNA-mRNA regulatory network to investigate the probable mechanism of circRNAs in ulcerative colitis. Initially, differentially expressed circRNAs (DEcircRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed mRNAs (DEmRNAs) were retrieved using the RNA expression spectrum of circRNA, miRNA, and mRNA in the Gene Expression Omnibus dataset. The competing endogenous RNA (ceRNA) network was then established after determining the DEcircRNA-DEmiRNA and DEmiRNA-DEmRNA interactions using bioinformatics analysis methods. Functional enrichment analysis was performed to evaluate the biological functions of DEmRNAs in the ceRNA network. Ultimately, DEcircRNAs in the circRNA-miRNA-mRNA network were used to construct a new diagnostic model.
Publish Date	2024-03-25 08:14
Citation	Yuan YY, Wu H, Chen QY, Fan H, Shuai B. Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis. World J Clin Cases 2024; 12(9): 1606-1621
URL	https://www.wjgnet.com/2307-8960/full/v12/i9/1606.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i9.1606

Full Article (PDF)	WJCC-12-1606-with-cover.pdf
Manuscript File	89070_Auto_Edited-YJP.docx
Answering Reviewers	89070-Answering reviewers.pdf
Audio Core Tip	89070-Audio core tip.m4a
Biostatistics Review Certificate	89070-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89070-Conflict-of-interest statement.pdf
Copyright License Agreement	89070-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89070-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	89070-Language certificate.pdf
Peer-review Report	89070-Peer-review(s).pdf
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Scientific Editor Work List	89070-Scientific editor work list.pdf
CrossCheck Report	89070-CrossCheck report.pdf