Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	89076
Country	China

Received	2023-10-19 16:30
Peer-Review Started	2023-10-19 16:31
To Make the First Decision
Return for Revision	2023-12-29 01:37
Revised	2024-01-10 06:12
Second Decision	2024-03-14 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-14 04:31
Articles in Press	2024-03-14 04:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-23 01:44
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Sheng Jin, Lu-Xi Chen, Ting-Ting Ji and Rong-Zhou Li
ORCID	Author(s) ORCID Number Xiao-Sheng Jin http://orcid.org/0000-0003-3833-114X Lu-Xi Chen http://orcid.org/0009-0002-9496-8946 Ting-Ting Ji http://orcid.org/0009-0003-7052-1880 Rong-Zhou Li http://orcid.org/0009-0002-5642-7882
Funding Agency and Grant Number	Funding Agency Grant Number Ruian Natural Science Foundation MS2021008
Corresponding Author	Rong-Zhou Li, MD, Professor, Department of Gastroenterology, The Third Affiliated Hospital of Wenzhou Medical University, No. 108 Wansong Road, Ruian 325000, Zhejiang Province, China. lrz23228@163.com
Key Words	Serpin peptidase inhibitor clade H member 1; Colorectal cancer; Proliferation; Cell cycle; Phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin
Core Tip	The expression of serpin peptidase inhibitor clade H member 1 (SERPINH1) was observed to be elevated in both colorectal cancer (CRC) cells and tissues at mRNA and protein levels. Increased SERPINH1 expression demonstrated a close association with the T stage, lymph node status, and distant metastasis in CRC patients, displaying a significant correlation with poor overall survival. Subsequent investigations revealed that the overexpression of SERPINH1 markedly enhanced the in vitro proliferation, invasion, and migration capabilities of CRC cells. Conversely, the knockdown of SERPINH1 resulted in the opposite effects. In addition, our study validated that the overexpression of SERPINH1 could stimulate the G1/S phase cell cycle transition through the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) pathways. Additionally, it was observed that the overexpression of SERPINH1 facilitated cell invasion and migration by modulating the PI3K/AKT/mTOR pathway. These findings emphasize the pivotal role of SERPINH1 in promoting CRC progression, providing insights into its potential as a therapeutic target for CRC treatment.
Publish Date	2024-05-09 13:59
Citation	Jin XS, Chen LX, Ji TT, Li RZ. SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway. World J Gastrointest Oncol 2024; 16(5): 1890-1907
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/1890.htm
DOI	10.4251/wjgo.v16.i5.1890

Full Article (PDF)	WJGO-16-1890-with-cover.pdf
Manuscript File	89076_Auto_Edited-YJP.docx
Answering Reviewers	89076-Answering reviewers.pdf
Audio Core Tip	89076-Audio core tip.mp3
Biostatistics Review Certificate	89076-Biostatistics statement.pdf
Clinical Trial Registration Statement	89076-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	89076-Conflict-of-interest statement.pdf
Copyright License Agreement	89076-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89076-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	89076-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	89076-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89076-Language certificate.pdf
Peer-review Report	89076-Peer-review(s).pdf
Scientific Misconduct Check	89076-Bing-Wang JJ-2.png
Scientific Editor Work List	89076-Scientific editor work list.pdf
CrossCheck Report	89076-CrossCheck report.pdf