Publication Name	World Journal of Hepatology
Manuscript ID	89081
Country	United States

Received	2023-10-25 13:54
Peer-Review Started	2023-10-19 20:04
First Decision by Editorial Office Director	2023-12-26 04:22
Return for Revision	2023-12-27 18:36
Revised	2024-01-17 19:16
Publication Fee Transferred
Second Decision by Editor	2024-02-26 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-02-26 06:05
Articles in Press	2024-02-26 06:05
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-11 02:35
Publish the Manuscript Online	2024-03-27 13:28

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Comparison of fungal vs bacterial infections in the medical intensive liver unit: Cause or corollary for high mortality?
Manuscript Source	Invited Manuscript
All Author List	Sarah Khan, Hanna Hong, Stephanie Bass, Yifan Wang, Xiao-Feng Wang, Omar T Sims, Christine E Koval, Aanchal Kapoor and Christina C Lindenmeyer
ORCID	Author(s) ORCID Number Sarah Khan http://orcid.org/0000-0002-4830-9176 Hanna Hong http://orcid.org/0000-0001-6637-8573 Stephanie Bass http://orcid.org/0000-0001-5175-0459 Yifan Wang http://orcid.org/0000-0002-4663-6202 Xiao-Feng Wang http://orcid.org/0000-0001-8212-6931 Omar T Sims http://orcid.org/0000-0002-3207-2231 Christine E Koval http://orcid.org/0000-0002-8196-2601 Aanchal Kapoor http://orcid.org/0000-0001-5130-2373 Christina C Lindenmeyer http://orcid.org/0000-0002-9233-6980
Funding Agency and Grant Number
Corresponding Author	Sarah Khan, MD, Doctor, Doctor, Department of Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, United States. khans21@ccf.org
Key Words	Fungal; Infection; Sepsis; Acute on chronic liver failure; Intensive care
Core Tip	In the critical care setting, patients with advanced liver disease who develop fungal infections have significantly higher mortality than those who develop bacterial infections. These patients require greater support with vasopressors, mechanical ventilation, and dialysis than their counterparts with bacterial infections. Patients who developed fungal infections appeared more acutely ill on admission to the intensive care unit, with higher Acute Physiology and Chronic Health Evaluation, Acute Physiology Score, and Model for End-Stage Liver Disease scores. In such patients, fungal infection development is closely associated with development of severe acute-on-chronic liver failure. Further work elucidating this relationship will allow for better prognostication and development of predictors for acute on chronic liver failure in this population.
Publish Date	2024-03-27 13:28
Citation	Khan S, Hong H, Bass S, Wang Y, Wang XF, Sims OT, Koval CE, Kapoor A, Lindenmeyer CC. Comparison of fungal vs bacterial infections in the medical intensive liver unit: Cause or corollary for high mortality? World J Hepatol 2024; 16 (3): 379-392
URL	https://www.wjgnet.com/1948-5182/full/v16/i3/379.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i3.379

Full Article (PDF)	WJH-16-379-with-cover.pdf