Publication Name	World Journal of Clinical Oncology
Manuscript ID	8910
Country	Brazil

Received	2014-01-11 14:31
Peer-Review Started	2014-01-11 17:32
To Make the First Decision	2014-02-27 09:41
Return for Revision	2014-03-10 20:36
Revised	2014-03-25 03:09
Second Decision	2014-05-29 08:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 09:41
Articles in Press	2014-05-29 11:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-21 16:10
Publish the Manuscript Online	2014-08-01 15:17

ISSN	2218-4333 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Topic Highlights
Article Title	Triiodothyronine and breast cancer
Manuscript Source	Invited Manuscript
All Author List	Maria Teresa De Sibio, Miriane de Oliveira, Fernanda Cristina Fontes Moretto, Regiane Marques Castro Olimpio, Sandro José Conde, Aline Carbonera Luvizon and Célia Regina Nogueira
Funding Agency and Grant Number
Corresponding Author	Dr. Maria Teresa De Sibio, Department of Internal Medicine, Botucatu Medical School, Univ Estadual Paulista-UNESP, Distrito de Rubi?o Jr s/n, Botucatu, SP 18618-970, Brazil. mt_bio@yahoo.com.br
Key Words	Thyroid hormone; Triiodothyronine; Breast cancer; Mammary gland and metabolism
Core Tip	Breast cancer (BC) is a malignant tumor occurring much more frequently in women than in men; worldwide, the incidence of BC has increased markedly in recent years. It is estimated that 1.7 million women will be diagnosed with BC in 2020, marking an increase of 26%, compared to the current incidence: 1.35 million new cases annually. Countless environmental risk factors, pathological conditions, and physiological agents, as well as thyroid hormones (THs), have been involved in the development of BC. Various lines of evidence suggest tumor-promoting effects of THs. The literature contains controversial reports regarding the relationship between thyroid diseases and BC; furthermore, studies reporting both an excess of and a lack of THs may affect breast development and progression to cancer. Epidemiologically, many studies suggest that hyperthyroidism is a factor in the development of BC. Furthermore, experimental studies have shown that high levels of THs reduce the interval of multiplication of BC cell lines. Therefore, the influence of THs on BC is unclear. However, the majority of BC research suggests a relationship, primarily, when the molecular aspects of these hormones are considered in the progression of this type of tumor.
Publish Date	2014-08-01 15:17
Citation	De Sibio MT, de Oliveira M, Moretto FCF, Olimpio RMC, Conde SJ, Luvizon AC, Nogueira CR. Triiodothyronine and breast cancer. World J Clin Oncol 2014; 5(3): 503-508
URL	http://www.wjgnet.com/2218-4333/full/v5/i3/503.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i3.503

Full Article (PDF)	WJCO-5-503.pdf
Full Article (Word)	WJCO-5-503.doc
Manuscript File	8910-Review.doc
Answering Reviewers	8910-Answering reviewers.pdf
Copyright License Agreement	8910-Copyright assignment.pdf
Peer-review Report	8910-Peer review(s).pdf
Scientific Misconduct Check	8910-CrossCheck.jpg
Scientific Editor Work List	8910-Scientific editor work list.pdf