Publication Name	World Journal of Stem Cells
Manuscript ID	89107
Country	China

Received	2023-10-20 13:31
Peer-Review Started	2023-10-20 13:32
To Make the First Decision
Return for Revision	2023-12-05 23:49
Revised	2023-12-15 07:38
Second Decision	2024-01-12 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-19 04:22
Articles in Press	2024-01-19 04:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-18 09:34
Publish the Manuscript Online	2024-02-26 04:10

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells
Manuscript Source	Invited Manuscript
All Author List	Yu-Su Wang, Wen-Hui Chu, Jing-Jie Zhai, Wen-Ying Wang, Zhong-Mei He, Quan-Min Zhao and Chun-Yi Li
ORCID	Author(s) ORCID Number Chun-Yi Li http://orcid.org/0000-0001-7275-4440
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China U20A20403
Corresponding Author	Chun-Yi Li, PhD, Professor, Institute of Antler Science and Product Technology, Changchun Sci-Tech University, No. 1345 Pudong Road, Changchun 130000, Jilin Province, China. lichunyi1959@163.com
Key Words	Osteochondral defect repair; Mesenchymal stem cells; Extracellular matrix; Decellularization; Antler stem cells; Reserve mesenchymal cells; Xenogeneic
Core Tip	Our study has shown that a decellularized xenogeneic extracellular matrix (ECM) derived from antler reserve mesenchymal cells, provided high quality repair of osteochondral defects in rat knee joints. This was achieved without detectable immune reaction in the recipient animals. This finding provides insights for the development of an effective therapeutic material for osteochondral defect repair and highlights the opportunity for use of this novel stem cell-derived ECM.
Publish Date	2024-02-26 04:10
Citation	Wang YS, Chu WH, Zhai JJ, Wang WY, He ZM, Zhao QM, Li CY. High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells. World J Stem Cells 2024; 16(2): 176-190
URL	https://www.wjgnet.com/1948-0210/full/v16/i2/176.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i2.176

Full Article (PDF)	WJSC-16-176-with-cover.pdf
Full Article (Word)	WJSC-16-176.docx
The ARRIVE Guidelines	89107-The ARRIVE guidelines.pdf
Manuscript File	89107_Auto_Edited-YJP.docx
Answering Reviewers	89107-Answering reviewers.pdf
Audio Core Tip	89107-Audio core tip.m4a
Biostatistics Review Certificate	89107-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89107-Conflict-of-interest statement.pdf
Copyright License Agreement	89107-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89107-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	89107-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	89107-Language certificate.pdf
Supplementary Material	89107-Supplementary material.pdf
Peer-review Report	89107-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	89107-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	89107-Bing-Wang JJ-2.png
Scientific Editor Work List	89107-Scientific editor work list.pdf
CrossCheck Report	89107-CrossCheck report.pdf