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Articles Published Processes
1/23/2024 4:13:00 AM | Browse: 254 | Download: 914
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Received |
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2023-10-23 15:37 |
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Peer-Review Started |
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2023-10-23 15:38 |
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First Decision by Editorial Office Director |
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2023-11-23 01:21 |
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Return for Revision |
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2023-11-23 01:21 |
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Revised |
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2023-12-10 15:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-12-28 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-12-28 07:46 |
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Articles in Press |
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2023-12-28 07:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-13 12:50 |
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Publish the Manuscript Online |
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2024-01-23 04:13 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie-Zhuang Huang, Jian-Di Li, Gang Chen and Rong-Quan He |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi Higher Education Undergraduate Teaching Reform Project |
2021JGA142 |
| Guangxi Educational Science Planning Key Project |
2022ZJY2791 |
| Guangxi Medical University Education and Teaching Reform Project |
2021XJGA02 |
| Guangxi Zhuang Autonomous Region Health Commission Self-financed Scientific Research Project |
Z20201147 |
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| Corresponding Author |
Rong-Quan He, MD, PhD, Doctor, Doctor, Researcher, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road
, Nanning 530021, Guangxi Zhuang Autonomous Region, China. herongquan@gxmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Transcatheter arterial embolisation refractoriness; Weighted gene co-expression network analysis; Single-cell RNA sequencing; AUCell; CellChat |
| Core Tip |
This is a study that explored the key genes and mechanisms related to transcatheter arterial chemoembolisation (TACE) refractoriness in hepatocellular carcinoma. Through the combination of tissue microarrays and RNA-seq with single-cell RNA sequencing, the TACE refractoriness-related genes were identified and five key genes (DLGAP5, KIF20A, ASPM, KIF11 and TPX2) associated with TACE refractoriness were revealed. The TACE refractoriness-related genes were found to mainly express in hepatocytes and embryonic stem cells. Hepatocytes providing ligands had the strongest interaction with embryonic stem cells as receptors providers. |
| Publish Date |
2024-01-23 04:13 |
| Citation |
Huang JZ, Li JD, Chen G, He RQ. Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma. World J Clin Oncol 2024; 15(1): 62-88 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i1/62.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i1.62 |
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