| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Ying Che, Ling Yuan, Jiao Min, Duo-Jie Xu, Dou-Dou Lu, Wen-Jing Liu, Kai-Li Wang, Yan-Yan Wang and Yi Nan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573695 |
| National Natural Science Foundation of China |
81860894 |
| National Natural Science Foundation of China |
81674096 |
| Ningxia Key Research and Development Plan Project |
2021BEG03106 |
|
| Corresponding Author |
Yi Nan, MD, Professor, Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080011@nxmu.edu.cn |
| Key Words |
Nardostachyos Radix et Rhizoma-rhubarb; Diabetic kidney disease; Molecular docking; Network pharmacology; Experimental validation |
| Core Tip |
The Nardostachyos Radix et Rhizoma-rhubarb drug pair may upregulate BCL-2 and STAT3 protein expression, and downregulate BAX, Caspase3, and Caspase9 protein expression, thus activating the advanced glycation end products (AGEs)-receptor for AGEs signaling pathway, inhibiting the vitality of TCMK-1 cells, reducing their apoptosis, and arresting them in the G0/G1 phase to protect them from damage by high glucose. |
| Publish Date |
2024-03-15 09:49 |
| Citation |
Che MY, Yuan L, Min J, Xu DJ, Lu DD, Liu WJ, Wang KL, Wang YY, Nan Y. Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification. World J Diabetes 2024; 15(3): 530-551 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i3/530.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i3.530 |
